| 小檗碱在抑制兔颈动脉粥样硬化形成中的作用 |
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| 引用本文： | 孙强,罗国君,艾志兵,何国厚,王建,欧阳静萍.小檗碱在抑制兔颈动脉粥样硬化形成中的作用[J].郧阳医学院学报,2010,29(5). |
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| 作者姓名： | 孙强 罗国君 艾志兵 何国厚 王建 欧阳静萍 |
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| 作者单位： | 孙强,SUN Qiang(武汉大学医学院病理生理教研室,湖北,武汉,434000;湖北医药学院附属太和医院神经内科,湖北,十堰,442000);罗国君,艾志兵,何国厚,LUO Guo-jun,AI Zhi-bing,HE Guo-hou(湖北医药学院附属太和医院神经内科,湖北,十堰,442000);王建,WANG Jian(浙江省富阳市人民医院神经内科,浙江,富阳,311400);欧阳静萍,OUYANG Jing-ping(武汉大学医学院病理生理教研室,湖北,武汉,434000) |
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| 摘 要： | 目的:探讨小檗碱抑制家兔颈动脉粥样硬化形成的作用机制。方法:24只雄性新西兰大白兔随机分为3组。正常对照组予普通饮食5周;模型组予高脂饲料喂养1周后,行右侧颈动脉内膜空气干燥术,再高脂喂养4周制作颈动脉粥样硬化模型;小檗碱处理组每日同时予颈动脉粥样硬化模型兔灌服小檗碱。观察颈动脉病理改变,并检测组织中巨噬细胞沉积和核因子-кB(NF-кB)、单核细胞趋化蛋白-1(MCP-1)表达情况。结果:模型组颈动脉有明显粥样硬化斑块形成,可见大量巨噬细胞沉积,NF-кB p65和MCP-1蛋白及mRNA表达明显(P<0.05),小檗碱组颈动脉硬化程度较轻,巨噬细胞明显减少,NF-кB p65和MCP-1蛋白及mRNA表达较模型组低(P<0.05),NF-кB与MCP-1二者呈正相关(r=0.958,P<0.01)。结论:小檗碱可能通过抑制NF-кB活性、降低MCP-1表达,减少巨噬细胞沉积而干预颈动脉粥样硬化形成。
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| 关 键 词： | 小檗碱 颈动脉粥样硬化 核因子-кB 单核细胞趋化蛋白-1 巨噬细胞 |
The Mechanism of Berberine on Preventing Carotid Atherosclerosis in Rabbits |
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| SUN Qiang,LUO Guo-jun,AI Zhi-bing,HE Guo-hou,WANG Jian,OUYANG Jing-ping.The Mechanism of Berberine on Preventing Carotid Atherosclerosis in Rabbits[J].Journal of Yunyang Medical College,2010,29(5). |
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| Authors: | SUN Qiang LUO Guo-jun AI Zhi-bing HE Guo-hou WANG Jian OUYANG Jing-ping |
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| Institution: | SUN Qiang1; 2; LUO Guo-jun2; AI Zhi-bing2; HE Guo-hou2; WANG Jian3; OUYANG Jing-ping1(1Department of Pathophysiology; Basic Medical College; Wuhan University; Wuhan; Hubei 430060; 2Department of Neurology; Taihe Hospital; Hubei University of Medicine; Shiyan; Hubei 442000; 3Department of Neurology; Fuyang Renmin Hospital; Fuyang; Zhejiang 311400; China); |
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| Abstract: | Objective To investigate the mechanism of berberine on preventing atherosclerosis(AS) in the carotid of rabbits.Methods Twenty-four New Zealand white rabbits were randomly divided into normal control group,carotid atherosclerosis model group and berberine group.The rabbits of control group were fed with normal diet.The model of carotid atherosclerosis was established with an air-drying operation on the right carotid and fed with a high cholesterol-diet in the second week for 4 weeks.The rabbits of berberine... |
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| Keywords: | Berberine Carotid atherosclerosis NF-кB Monocyte chemoattractant protein-1 Macrophage cell |
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