| 合欢皮水煎剂催眠作用的药理实验研究 |
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| 引用本文： | 霍长虹,郝存书,李作平,梁燕,刘久弟,王佛华,付超美.合欢皮水煎剂催眠作用的药理实验研究[J].河北医科大学学报,2002,23(4):216-217. |
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| 作者姓名： | 霍长虹 郝存书 李作平 梁燕 刘久弟 王佛华 付超美 |
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| 作者单位： | 1. 河北医科大学药学院天然药物化学教研室,河北,石家庄,050017
2. 河北医科大学药学系1997级毕业生,河北,石家庄,050017 |
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| 摘 要： | 目的 考察合欢皮水煎剂对戊巴比妥钠诱导小白鼠产生催眠作用的量效关系。方法 用三种不同浓度合欢皮水煎液给予小予灌胃，就其对戊巴比妥钠的催眠作用所产生的影响进行比较。结果 中、低浓度合欢皮水煎液可协同戊巴比妥钠缩短睡眠潜伏期及延长睡眠时间（P＜0.01)，高浓度合欢皮水煎剂则对小白鼠有兴奋作用（P＜0.01)。结论 合欢皮具有双向调节作用；提示合欢皮在临床用于失眠症时，似以较低剂量为佳。
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| 关 键 词： | 合欢皮水煎剂 催眠作用 药理学 合欢 失眠症 |
| 文章编号： | 1007-3205(2002)04-0216-02 |
| 修稿时间： | 2001年6月29日 |
PHARMACOLOGICAL STUDY ON HYPNOSIS EFFECT OF CORTEX ALBIZIAE SOLUTION |
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| HUO Chang-hong ,HAO Cun-shu ,LI Zuo-ping ,LIANG Yan ,LIU Jiu-di ,WANG Fo-hua ,FU Chao-mei.PHARMACOLOGICAL STUDY ON HYPNOSIS EFFECT OF CORTEX ALBIZIAE SOLUTION[J].Journal of Hebei Medical University,2002,23(4):216-217. |
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| Authors: | HUO Chang-hong HAO Cun-shu LI Zuo-ping LIANG Yan LIU Jiu-di WANG Fo-hua FU Chao-mei |
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| Institution: | HUO Chang-hong 1,HAO Cun-shu 1,LI Zuo-ping 1,LIANG Yan 2,LIU Jiu-di 2,WANG Fo-hua 1,FU Chao-mei 1 |
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| Abstract: | ObjectiveTo study the effect of Cortex Albiziae solution pentobarbital-induced hypnosis in mice. MethodsThree doses of Cortex Albiziae solution were chosen to study their interaction with the hypnosis effect induced by pentobarbital sodium in mice.ResultsThe low and the middle doses of Cortex Albiziae could significantly shorten the latency of sleep and prolong the time of sleep in mice (P< 0.01 ). The high dose of Cortex Albiziae had significant stimulation (P< 0.01 ). ConclusionCortex Albiziae has double-direction adjustment effect, suggesting that the lower dose of Cortex Albiziae would be used in the treatment of insomnia. |
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| Keywords: | Cortex Albiziae hypnosis/pharmacology mice |
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