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| 急性重症胰腺炎并发肺损伤时内皮素和一氧化氮变化的实验研究 | |
| 引用本文： | 赵雪峰,李勇,邝钢,赵群,范立桥,郭明,王晓玲.急性重症胰腺炎并发肺损伤时内皮素和一氧化氮变化的实验研究[J].河北医科大学学报,2003,24(1):4-6,F003. |
| 作者姓名： | 赵雪峰 李勇 邝钢 赵群 范立桥 郭明 王晓玲 |
| 作者单位： | 1. 河北医科大学第四医院外三科,河北,石家庄,050011 2. 河北省肿瘤研究所,河北,石家庄,050011 3. 河北医科大学第四医院病理科,河北,石家庄,050011 |
| 摘 要： | 目的：探讨急性重症胰腺炎并发肺损伤时内皮素（endothelins,ET）和一氧化氮（nitric oxide,NO）的作用。方法：胰胆管逆行注药法制备大鼠急性重症胰腺炎并发肺损伤模型，检测血浆ET、NO、淀粉酶（amylase,AMY)、脂肪酶（lipase,LIP)水平；胰腺、肺脏系数和胰腺、肺脏病理形态变化。结果：急性重症胰腺炎并发肺损伤模型中血浆ET、NO、AMY、LIP水平，胰腺、肺脏系数均明显升高；胰、肺病理形态改变明显。结论：ET、NO在急性重症胰腺炎并发肺损伤发病中起重要作用。 |
| 关 键 词： | 急性重症胰腺炎 肺损伤 内皮素 一氧化氮 内皮缩血管肽类 SAP |
| 文章编号： | 1007-3205(2003)01-0004-03 |
STUDY OF CHANGES OF ENDOTHELINS AND NITRIC OXIDE IN SEVERE ACUTE PANCREATITIS WITH LUNG INJURY |
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| ZHAO Xue feng ,LI Yong ,KUANG Gang ,ZHAO Qun ,FAN Li qiao ,GUO Ming ,WANG Xiao ling.STUDY OF CHANGES OF ENDOTHELINS AND NITRIC OXIDE IN SEVERE ACUTE PANCREATITIS WITH LUNG INJURY[J].Journal of Hebei Medical University,2003,24(1):4-6,F003. | |
| Authors: | ZHAO Xue feng LI Yong KUANG Gang ZHAO Qun FAN Li qiao GUO Ming WANG Xiao ling |
| Institution: | ZHAO Xue feng 1,LI Yong 1,KUANG Gang 2,ZHAO Qun 1,FAN Li qiao 1,GUO Ming 3,WANG Xiao ling 3 |
| Abstract: | ObjectiveTo study the role of endothelins(ET) and nitric oxide (NO) in the episode of severe acute pancreatitis(SAP) with lung injury. MethodsSAP model was induced by retrograde injection of sodium tanrocholate to pancreatic duct. Plasma level of ET, NO, amylase(AMY) and lipase(LIP),pancreatic and lung index were detected. Pancreatic and lung pathologic changes were observed.ResultsThe plasma level of ET, NO, AMY and LIP, pancreatic and lung index in SAP groups increased significantly. Pancreatic and lung pathologic changes in SAP groups changed significantly. ConclusionNO and ET play important roles in episode of SAP with lung injury. |
| Keywords: | pancreatitis acute necrotizing lung/inj endothelins nitric oxide rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |