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光量子氧疗对脑梗死患者TXA2-PGI2平衡及脑血流的影响
引用本文:张玉梅,李明洲,么崇政. 光量子氧疗对脑梗死患者TXA2-PGI2平衡及脑血流的影响[J]. 河北医科大学学报, 2003, 24(2): 73-76
作者姓名:张玉梅  李明洲  么崇政
作者单位:1. 北京市崇文区中医院内二科,北京,100061
2. 卫生部北京医院,北京,100730
3. 中日友好医院,北京,100029
摘    要:目的旨在观察光量子氧疗对脑梗死患者血栓素A2 前列腺素I2 平衡及脑血流的影响。方法将脑梗死后 3~ 10周患者 10 8例随机分为两组。A组予丹参液静脉滴注 ,B组予充氧光量子化丹参液静脉滴注 2周。治疗前、后分别做神经功能缺损程度评分、测定血浆血栓素B2 (thromboxaneB2 ,TXB2 )和 6 酮 前列腺素F1α(6 k PGF1α)含量、经颅血流多普勒超声测定大脑中动脉血流的平均峰流速 (meanvelocity ,Vm )并计算两侧的非对称指数。结果治疗前后两组的神经功能缺损程度评分均显著降低 ,但B组降低的幅度显著大于A组。B组的总有效率显著高于A组。两组血浆TXB2 和TXB2 / 6 k PGF1α比值在治疗后均显著降低 ,但B组降低的幅度显著大于A组。而且B组在治疗后 6 k PGF1α显著上升 ,而A组变化不显著。两组患侧Vm治疗后均显著增加 ,但B组增加的幅度显著大于A组。而且B组在治疗后Vm的非对称指数显著降低 ,非对称性病例显著减少 ,而A组变化不显著。血浆TXB2 、TXB2 / 6 k PGF1α比值与患侧Vm之间均呈显著负相关。结论光量子氧疗可显著促进纠正脑梗死患者恢复期的TXA2 PGI2 失衡 ,并加速患侧大脑中动脉血流的恢复 ,光量子氧疗的临床疗效可能与这些作用有关

关 键 词:脑梗塞  紫外线疗法  血栓素B  前列腺素F类  超声检查  多普勒  经颅
文章编号:1007-3205(2003)02-0073-04
修稿时间:2002-02-25

EFFECTS OF ULTRAVIOLET LIQUID IRRADIATION AND OXYGENATION ON THE IMBALANCE OF TXA2-PGI2 AND CEREBRAL BLOOD FLOW IN PATIENTS WITH CEREBRAL INFARCTION
ZHANG Yu mei ,LI Ming zhou ,YAO Chong zheng. EFFECTS OF ULTRAVIOLET LIQUID IRRADIATION AND OXYGENATION ON THE IMBALANCE OF TXA2-PGI2 AND CEREBRAL BLOOD FLOW IN PATIENTS WITH CEREBRAL INFARCTION[J]. Journal of Hebei Medical University, 2003, 24(2): 73-76
Authors:ZHANG Yu mei   LI Ming zhou   YAO Chong zheng
Affiliation:ZHANG Yu mei 1,LI Ming zhou 2,YAO Chong zheng 3
Abstract:ObjectiveTo observe the effe cts of ultraviolet liquid irradiation and oxygenation (ULIO) on the imbalance of TXA 2 PGI 2 and cerebral blood flow in patients with cerebral infarction. Methods108 patients with cerebral infarction 3 10 weeks after the attack were randomized into 2 groups. Group A were dripped intravenously with Danshen while group B with Danshen and ULIO for 2 weeks. Plasma TXB 2, 6 keto PGF1 alpha were determined, mean peak flow velocity of bilateral mid cerebral artery (MCA Vm) were measured from transcranial Doppler sonography, and the interhemispheric asymmetry indexes were calculated. ResultsAfter 2 weeks of treatment, there were significant decreases of neurological functional defect scores in both groups, but the decreas in group B was significantly larger than that in group A. The total effective rate in group B was significantly higher than that in group A. There were significant decreases of TXB 2 and TXB 2/6 keto PGF1 alpha ratio in both groups, but the decreases in group B were significantly larger than those in gro up A. There was a significant increase of 6 keto PGF1 alpha in group B but not in group A. MCA Vm of the diseased side was increased significantly in b oth gro ups, but the increase in group B was significantly larger than that in group A. The interhemispheric asymmetry index and the patients of asymmetry were significantly decreased in group B but not in group A. There were significant linear inverse correlations between MCA Vm of the diseased side and TXB 2 or the ratio of TXB 2/6 keto PGF1 alpha. ConclusionULIO can promote correction of the imbalance of TXA 2 PGI 2 and accelerate restoration of blood flow of diseased artery. These can partly contribute to the clinical beneficial effects of ULIO in patients with cerebral infarction.
Keywords:cerebral infarction  ultraviolet therapy  thromboxane B 2  prostaglandins F  ultrasonography  Doppler  transcranial
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