光量子氧疗对脑梗死患者TXA2-PGI2平衡及脑血流的影响

目的旨在观察光量子氧疗对脑梗死患者血栓素A2 前列腺素I2 平衡及脑血流的影响。方法将脑梗死后 3～ 10周患者 10 8例随机分为两组。A组予丹参液静脉滴注 ,B组予充氧光量子化丹参液静脉滴注 2周。治疗前、后分别做神经功能缺损程度评分、测定血浆血栓素B2 (thromboxaneB2 ,TXB2 )和 6 酮 前列腺素F1α(6 k PGF1α)含量、经颅血流多普勒超声测定大脑中动脉血流的平均峰流速 (meanvelocity ,Vm )并计算两侧的非对称指数。结果治疗前后两组的神经功能缺损程度评分均显著降低 ,但B组降低的幅度显著大于A组。B组的总有效率显著高于A组。两组血浆TXB2 和TXB2 / 6 k PGF1α比值在治疗后均显著降低 ,但B组降低的幅度显著大于A组。而且B组在治疗后 6 k PGF1α显著上升 ,而A组变化不显著。两组患侧Vm治疗后均显著增加 ,但B组增加的幅度显著大于A组。而且B组在治疗后Vm的非对称指数显著降低 ,非对称性病例显著减少 ,而A组变化不显著。血浆TXB2 、TXB2 / 6 k PGF1α比值与患侧Vm之间均呈显著负相关。结论光量子氧疗可显著促进纠正脑梗死患者恢复期的TXA2 PGI2 失衡 ,并加速患侧大脑中动脉血流的恢复 ,光量子氧疗的临床疗效可能与这些作用有关

EFFECTS OF ULTRAVIOLET LIQUID IRRADIATION AND OXYGENATION ON THE IMBALANCE OF TXA2-PGI2 AND CEREBRAL BLOOD FLOW IN PATIENTS WITH CEREBRAL INFARCTION

ObjectiveTo observe the effe cts of ultraviolet liquid irradiation and oxygenation (ULIO) on the imbalance of TXA 2 PGI 2 and cerebral blood flow in patients with cerebral infarction. Methods108 patients with cerebral infarction 3 10 weeks after the attack were randomized into 2 groups. Group A were dripped intravenously with Danshen while group B with Danshen and ULIO for 2 weeks. Plasma TXB 2, 6 keto PGF1 alpha were determined, mean peak flow velocity of bilateral mid cerebral artery (MCA Vm) were measured from transcranial Doppler sonography, and the interhemispheric asymmetry indexes were calculated. ResultsAfter 2 weeks of treatment, there were significant decreases of neurological functional defect scores in both groups, but the decreas in group B was significantly larger than that in group A. The total effective rate in group B was significantly higher than that in group A. There were significant decreases of TXB 2 and TXB 2/6 keto PGF1 alpha ratio in both groups, but the decreases in group B were significantly larger than those in gro up A. There was a significant increase of 6 keto PGF1 alpha in group B but not in group A. MCA Vm of the diseased side was increased significantly in b oth gro ups, but the increase in group B was significantly larger than that in group A. The interhemispheric asymmetry index and the patients of asymmetry were significantly decreased in group B but not in group A. There were significant linear inverse correlations between MCA Vm of the diseased side and TXB 2 or the ratio of TXB 2/6 keto PGF1 alpha. ConclusionULIO can promote correction of the imbalance of TXA 2 PGI 2 and accelerate restoration of blood flow of diseased artery. These can partly contribute to the clinical beneficial effects of ULIO in patients with cerebral infarction.