何首乌的抗衰老作用研究

目的：探讨何首乌对抗D－半乳糖所致亚急性衰老的机制。方法：将小鼠30只随机分为3组：对照组、衰老模型组和何首乌治疗组。衰老模型组、何首乌治疗组用D－半乳糖皮下注射，1次／d，连续6周造成小鼠衰老。第3周时，何首乌治疗组给小鼠灌胃何首乌。第6周末处死。测定不同组织脂褐质（lipofuscin,LPF)、Na^ /K^ -ATP酶（Na^ /K^ -ATPase）、超氧化物歧化酶（superoxide dismutase,SOD）和丙二醛含量。结果：何首乌可降低小鼠脑组织和肾组织的LPF含量，升高心肌Na^ /K^ -ATPase活性和肝脏SOD活性。结论：何首乌具有抗衰老作用，其机制是通过多种途径而实现的。

STUDY ON THE ANTI-AGING EFFECTS OF RADIX POLYGONUM MULTIFLORUM

ObjectiveTo investigate the effects of R adix Polygonum multiflorum (RPM)on sub acute aging mice induced by D galactose.MethodsMice were divided randomly into three groups: control group, model group and RPM group. Mice in model group and RPM group were subcutaneously injected with D galactose for 6 weeks.Beginning from the third week of D galactose treatment,mice in RPM group were orally administrated with RPM. The mice were killed at the end of the sixth week. The level of lipofuscin(LPF) and malondialdehyde(MDA) as well as the activeties of Na +/K + ATPase and superoxide dismutase(SOD) were measured. ResultsRPM could decrease the level of LPF in brain and kidney,enhance the activities of Na +/K + ATPase in heart and SOD in liver.ConclusionRPM has some anti aging effects on sub acute aging mice.