瘦素在妊娠合并非酒精性脂肪肝孕期的序贯观察

目的 观察瘦素在妊娠合并非酒精性脂肪肝孕期的序贯变化.方法 选择我院产检门诊孕周小于12周的病例入组,据病史采集并于孕早期行肝脏超声检查,据结果将孕妇分为研究组及对照组.于孕期三阶段分别采集血液标本检测瘦素水平进行序贯观察,于孕中期行OGTT检查了解妊娠合并非酒精性脂肪肝孕期胰岛β细胞功能受损情况.结果 研究组孕妇孕期三阶段外周血血清瘦素水平分别与对照组相比,差异均有统计学意义（P＜0.01）;研究组孕中期及孕晚期瘦素水平与孕早期相比,差异均有统计学意义（P＜0.01）;研究组中行OGTr异常诊断为GDM者有12例,发病率为38.7％;对照组中GDM患者有3例,发病率5.8％.两组GDM发病率相比,差异有统计学意义（P＜0.01）.结论 妊娠合并非酒精性脂肪肝患者存在高瘦素血症,与其孕期GDM发病率高有相关性.

Sequential observation of leptin in pregnant women with non-alcoholic fatty liver of pregnancy

Objective To observe sequential change of leptin in pregnant women with non-alcoholic fatty liver. Methods Cases of gestational age less than 12 weeks were enrolled, then went to history taking and underwent liver ultrasound in early pregnancy, according to the results, study group and control group were set up. Blood samples were collected at three stages during pregnancy in detection of leptin levels sequential observation. And in the second trimester OGTI＂ check of pregnant women with non-alcoholic fatty liver of pregnancy in order to learn about the dysfunction of beta cell. Results Compared with the control group, study group got higher blood serum leptin levels during three-stage pregnancy, and the differences were statis- tically significant （P 〈 0. 01 ） ; in the second trimester and third trimester of pregnancy, leptin levels of study group compared with the first trimester, the differences were statistical significance （P 〈 0. 01 ） ; 12 patients were diagnosed in study group, the incidence was 38.7% ; 3 cases of GDM patients in the control group with incidence rate of 5.8%. As to the incidence of GDM between the two groups, difference was statistically significant （ P 〈 0.01 ）. Conclusion There is high leptin levels in preg- nant women with non-alcoholic fatty liver disease, with its high incidence of GDM during pregnancy.