Sirius和Lenstar及A超测量中央角膜厚度的对比研究

目的 比较Sirius、Lenstar及A超测量中央角膜厚度（CCT）的差异,并对测量结果进行一致性评价.方法 对52例（104眼）近视眼患者,依次采用Sirius、Lenstar及A超测量CCT.配对t检验和Pearson相关分析评价CCT测量值两两间的差异及相关关系,Bland-Altman分析评价一致性.结果 Sirius与A超、Lenstar与A超的CCT测量值之间差异均有统计学意义,而Sirius与Lenstar的CCT测量值比较差异无统计学意义.三种仪器测量CCT具有显著的正相关性.CCT测量值95％一致性界限分别为Sirius与A超（-16.7,8.0）μm、Lenstar与A超（-19.7,8.5）μm、Sirius与Lenstar（-12.8,15.3）μm.结论 Sirius、Lenstar与A超测量CCT之间具有较高的一致性,可作为角膜中央厚度测量的常规工具.Sirius和Lenstar测量值与A超相比,存在差异,前二者低估了中央角膜厚度.

Comparative study of central corneal thickness measurements with Sirius,Lenstar and Ultrasound pachymetry

Objective To assess the differences and agreements among measurements of central corneal thickness （CCT） using Sirius, Lenstar and ultrasound pachymetry （USP） . Methods The CCT of 104 eyes from 52 patients with myopia were measured with Sirius, Lenstar and ultrasound pachymetry. Data were compared by using paired t-tests and the Pearson correlations. Bland-Altman analysis of all pairs were determined. Results The difference between Sirius and USP, Lenstar and USP were statistically significant （P 〈 0. 001 ）, but the CCT measured by Sirius and Lenstar had no statistically significant difference （P 〉 0.05 ） . There was high correlation between the three instruments. The 95% limits of agreement for central cor- neal thickness measurements were - 16. 7μm to ＋ 8. 0μm between Sirius and USP, - 19.7μm to ＋ 8. 5μm between Lenstar and USP, and - 12. 8μm to ＋ 15.3μm between Sirius and Lenstar. Conclusion Central corneal thickness obtained with the USP were similar to those obtained with both the Sirius and Lenstar. They all can be used as a routine tool of central corneal thickness measurement. But compared with USP, Sirius and Lenstar may underestimate the central corneal thickness.