| 5-羟色胺受体及转运体在肠易激综合征发病机制中的作用 |
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| 引用本文： | 王静.5-羟色胺受体及转运体在肠易激综合征发病机制中的作用[J].上海交通大学学报(医学版),2008,28(8). |
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| 作者姓名： | 王静 |
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| 作者单位： | 上海交通大学医学院瑞金医院消化内科 上海200025 |
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| 摘 要： | 肠易激综合征(IBS)是一种慢性功能性肠道疾病。IBS具有肠道动力异常、肠内分泌紊乱和内脏高敏感等特点。5-羟色胺(5-HT)是肠道重要的神经递质,通过各受体亚型及转运体在IBS发病中介导了不同的生理及病理效应,引起肠道功能异常。近年研究发现5-HT受体及转运体的相关制剂在IBS治疗中显示了良好的应用前景。
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| 关 键 词： | 肠易激综合征 5-羟色胺受体 5-羟色胺转运体 |
Roles of serotonin receptors and transporters in pathogenesis of irritable bowel syndrome |
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| WANG Jing,ZHU Qi.Roles of serotonin receptors and transporters in pathogenesis of irritable bowel syndrome[J].Journal of Shanghai Jiaotong University:Medical Science,2008,28(8). |
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| Authors: | WANG Jing ZHU Qi |
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| Abstract: | Irritable bowel syndrome(IBS) is a functional gastrointestinal disorder.Alterations in motility,secretion and visceral sensation are hallmarks of IBS.As an important neurotransmitter,5-hydroxytryptamine(5-HT) can induce abnormal gastrointestinal function through different physiological and pathological effects.Various agents of 5-HT receptor and serotonin transporter have been found efficacious in the treatment of IBS. |
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| Keywords: | irritable bowel syndrome 5-hydroxytryptamine receptor serotonin transporter |
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