血清松弛素浓度与女性盆底器官脱垂关系的研究

目的 研究血清松弛素浓度与女性盆底器官脱垂(POP)及绝经的关系.方法 选择POP患者39例(POP组),另设盆底功能正常的39名妇女为对照组；分析POP与血清松弛索水平的关系以及绝经对血清松弛素水平的影响.结果 POP组的血清松弛素质量浓度为(406.7±311.2)ng/L,对照组为(199.4±208.7) ng/L,差异有统计学意义(P＜0.05)；绝经后妇女的血清松弛素质量浓度为(172.0±197.5) ng/L,未绝经妇女为(587.5±716.8) ng/L,差异有统计学意义(P＜0.05) ;POP组中已绝经患者的血清松弛素质量浓度为(226.2±178.8) ng/L,对照组中已绝经妇女(108.4±98.7) ng/L,差异有统计学意义(P ＜0.05) ;POP组中未绝经患者的血清松弛素质量浓度为( 1870.2±264.4)ng/L,对照组中未绝经妇女为(373.7±370.4) ng/L,差异具有统计学意义(P ＜0.001).结论 血清松弛索水平升高可能是妇女发生POP的病因.

Relationship between serum relaxin levels and female pelvic floor prolapse

Objective To investigate the correlation of serum relaxin level with female pelvic organ prolapse(POP) and menopause.Methods Thirty-nine patients with POP(POP group) were selected,and another 39 women with normal pelvic floor function were served as control group.The relationship between POP and serum relaxin level was analysed,and the effect of menopause on serum relaxin level was investigated.Results The mass concentrations of serum relaxin in POP group and control group were(406.7±311.2) ng/L and(199.4±208.7) ng/L respectively,and there were significant differences between two groups(P<0.05).The mass concentrations of serum relaxin of menopausal women and non-menopausal women were(172.0±197.5) ng/L and(587.5±716.8) ng/L respectively,and there were significant differences between two groups(P<0.05).The mass concentrations of serum relaxin of menopausal women in POP group and in control group were(226.2±178.8) and(108.4±98.7) ng/L respectively,and there were significant differences between two groups(P<0.05).The mass concentrations of serum relaxin of non-menopausal women in POP group and in control group were(1870.2±264.4) ng/L and(373.7±370.4) ng/L respectively,and there were significant differences between two groups(P<0.001).Conclusion The elevation of serum relaxin level may be the cause of female POP.