| 炎症性肠病Toll样受体的基因多态性及其在不同人群中的分布 |
| |
| 引用本文： | 薛惠平,倪培华,吴洁敏,童菊芳.炎症性肠病Toll样受体的基因多态性及其在不同人群中的分布[J].上海交通大学学报(医学版),2007,27(10):1226-1231. |
| |
| 作者姓名： | 薛惠平 倪培华 吴洁敏 童菊芳 |
| |
| 作者单位： | 上海交通大学医学院仁济医院消化内科上海市消化疾病研究所 上海200001(薛惠平，童菊芳)，上海交通大学医学院检验系 上海200001(倪培华，吴洁敏) |
| |
| 摘 要： | 目的了解上海地区汉族炎症性肠病(IBD)患者TLR4(Asp299Gly、Thr399Ile)和TLR2的基因(Arg677Trp、Arg753Gln)多态性,探讨其多态性与IBD的相关性,并与其他国家不同人群中该基因多态性分布进行比较。方法采用PCR-RFLP法,对IBD组(n=84)和健康对照组(n=135)进行TLR4(Asp299Gly、Thr399Ile)和TLR2的基因(Arg677Trp、Arg753Gln)多态性检测,PCR产物进行核苷酸序列分析。结果在IBD组和对照组中均未发现TLR4突变基因(Asp299Gly、Thr399Ile)和TLR2突变基因(Arg677Trp、Arg753Gln)。结论TLR4基因(Asp299Gly、Thr399Ile)和TLR2基因(Arg677Trp、Arg753Gln)多态性与上海地区汉族人群IBD易感性无明显相关性;在其他国家不同人群中分布的多态性可能是由种族差异所造成的。
|
| 关 键 词： | 炎症性肠病 Toll样受体 单核苷酸多态性 |
| 文章编号： | 0258-5898（2007）10-1226-06 |
| 修稿时间： | 2007-04-20 |
Gene polymorphisms of Toll-like receptors in inflammatory bowel disease and their distribution in different populations |
| |
| XUE Hui-ping,NI Pei-hua,WU Jie-min,TONG Ju-fang.Gene polymorphisms of Toll-like receptors in inflammatory bowel disease and their distribution in different populations[J].Journal of Shanghai Jiaotong University:Medical Science,2007,27(10):1226-1231. |
| |
| Authors: | XUE Hui-ping NI Pei-hua WU Jie-min TONG Ju-fang |
| |
| Institution: | 1. Department of Gastroenterology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China ; 2. Faculty of Laboratory Medicine, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China |
| |
| Abstract: | Objective To probe the gene polymorphisms of TLR4(Asp299Gly and Thr399Ile) and TLR2(Arg677Trp and Arg753Gln) in patients with inflammatory bowel disease(IBD)among Han population in Shanghai,investigate the correlation with IBD,and compare the gene polymorphism distribution among different populations of various countries. Methods Polymorphisms of TLR4(Asp299Gly and Thr399Ile) and TLR2(Arg677Trp and Arg753Gln) were genotyped respectively in 84 patients with IBD and 135 healthy controls by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP). Results The mutant genotypes of TLR4 gene(Asp299Gly and Thr399Ile) as well as TLR2 gene(Arg677Trp and Arg753Gln) were not found in both IBD group and controls.Conclusion TLR4 gene(Asp299Gly and Thr399Ile) and TLR2 gene(Arg677Trp and Arg753Gln) polymorphisms may not be correlated with IBD susceptibility among Han population in Shanghai.The polymorphism distribution among different populations in other countries may be engendered by genetic heterogeneity. |
| |
| Keywords: | inflammatory bowel disease Toll-1ike receptor single nucleotide polymorphism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
