| 实验性大鼠肾草酸钙结石模型的筛选研究 |
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| 引用本文： | 李文峰,施国海,顾欣,张士青.实验性大鼠肾草酸钙结石模型的筛选研究[J].上海交通大学学报(医学版),2006,26(1):66-68. |
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| 作者姓名： | 李文峰 施国海 顾欣 张士青 |
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| 作者单位： | 上海交通大学医学院第三人民医院泌尿外科 上海201900 |
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| 基金项目： | 上海市自然科学基金(024119087)资助项目 |
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| 摘 要： | 目的筛选简捷且成石效果好的实验性大鼠肾草酸钙结石造模法。方法采用两类10种诱导法制作大鼠肾草酸钙结石模型,比较各组大鼠24h尿草酸排泄量和肾组织草酸钙结晶情况,综合评价10种造模法。结果10种造模法组的24h尿草酸排泄量及草酸钙结晶评分均显著高于空白对照组(P<0.05),其中1%乙二醇 1%氯化胺饮水1周建模效果好,且耗时最短。结论1%乙二醇 1%氯化铵饮水1周为首选造模法。
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| 关 键 词： | 尿路结石 草酸钙 动物模型 大鼠 |
| 文章编号： | 0258-5898(2006)01-0066-03 |
| 收稿时间： | 2005-07-06 |
| 修稿时间： | 2005年7月6日 |
Comparison of the Experimental Renal Calcium Oxalate Calculus Models in Rats |
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| LI Wen-feng,SHI Guo-hai,GU Xin,ZHANG Shi-qing.Comparison of the Experimental Renal Calcium Oxalate Calculus Models in Rats[J].Journal of Shanghai Jiaotong University:Medical Science,2006,26(1):66-68. |
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| Authors: | LI Wen-feng SHI Guo-hai GU Xin ZHANG Shi-qing |
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| Abstract: | Objective To select a simple, fast and satisfied model of renal calcium oxalate calculus in rats. Methods After ten renal calcium oxalate calculus models in rats were developed with calculus inducers,the scores of calcium oxalate crystallization within the kidney and 24h urinary oxalate excretion were measured. Results Calcium oxalate crystallization and 24h urinary oxalate excretion of each calculus inducing model group were significantly higher than those of control group (P<0.05). The method of 1% ethylene glycol plus 1% ammonia chloride for one week had good effect and is least time-consuming. Conclusion The method of 1% ethylene glycol plus 1% ammonia chloride for one week is the first choice of modeling renal calcium oxalate calculus. |
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| Keywords: | urinary calculi calcium oxalate animal model rat |
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