小肠细菌过度生长在肠易激综合征发病机制中的作用

小肠细菌过度生长(SIB0)是指远端肠道内菌群因各种原因移位进入小肠,引起小肠内厌氧菌过度孳生而表现为营养吸收不良、腹泻、腹胀及小肠动力异常等症状的临床综合征.SIB0与肠易激综合征(IBS)的症状重叠.相关研究表明SIB0与IBS具有相关性;推测SIB0可能是IBS发生的一种潜在的病原性因素.该文就近年来SIB0在IBS发病机制中作用的研究进展作一综述.

Roles of small intestinal bacterial overgrowth in pathogenesis of irritable bowel syndrome

Small intestinal bacterial overgrowth (SIBO) refers to a condition in which abnormally large numbers of anaerobic bacteria present in the small intestine, and patients with SIBO typically complain of diarrhea, bloating and some symptoms induced by malabsorption and dysfunction of intestinal transit. The symptoms of SIBO are similar to those of irritable bowel syndrome (IBS). Relevant studies have revealed that SIBO is related to IBS, and it has been hypothesized that SIBO may be an underlying cause for IBS. The research progress of roles of SIBO in the pathogenesis of IBS is reviewed in this paper.