脑源性神经营养因子在抑郁症发作病理机制中的作用

抑郁症的脑源性神经营养因子(BDNF)假说认为,BDNF减少在抑郁症的病理生理机制中起着重要的作用,而且其恢复可能与抗抑郁治疗有关.该理论已经得到了越来越多的新证据证明.BDNF能通过多种途径调控神经细胞的发生、生存、生长、分化和凋亡,并直接参与了神经突触的可塑性和重构,这可能是BDNF参与抑郁症发病和治疗的重要机制.该文就近来的BDNF与抑郁症的相关研究进行综述.

Role of brain-derived neurotrophic factor in pathological mechanism of major depressive disorder episode

The brain-derived neurotrophic factor (BDNF) hypothesis of depression postulates that the decrease of BDNF plays a major role in the pathophysiology of major depressive disorder, and its restoration may be associated with the efficacy of antidepressant treatment. This theory has been confirmed by increasingly more evidences. BDNF plays a critical role in neurogenesis, neuronal survival, development, differentiation and regeneration, and directly involves in synaptic plasticity and reconstruction, which is probably the important molecular mechanism responsible for the onset and antidepressant action of depression. The research advance on relationship between BDNF and major depressive disorder is reviewed in this paper.