视觉P300电位在精神分裂症司法鉴定责任能力评定中的初步应用

目的探讨视觉P300在精神分裂症司法鉴定责任能力评定中的价值。方法分别对经司法鉴定为无责任能力的精神分裂症患者（n=68，无责任能力组）和限定责任能力的精神分裂症患者（n=59，限定责任能力组）进行视觉司法事件相关脑电位P300检测，以58名志愿受试者作为对照（正常组）。结果与正常组比较，无责任能力组和限定责任能力组P300电位成分中N1、N2和P3潜伏期显著延长（P〈0．01），P3波幅显著降低（P〈0．01）。无责任能力组P300电位成分中N1、N2和P3潜伏期较限定责任能力组显著延长，P3波幅则显著降低，组间比较差异均有统计学意义（P〈0．01）。结论视觉P300在精神分裂症司法鉴定责任能力评定中有一定的参考意义，但研究结果还有待进一步随访验证。

Preliminary study on application of visual P300 potentials in responsible appreciation of schizophrenia patients by judicial expertise

Objective To explore the value of visual P300 potentials in responsible appreciation of schizophrenia patients by judicial expertise. Methods Sixty-eight schizophrenia patients without responsible ability （group A） and 59 schizophrenia patients with limited responsible ability （group B） by judicial expertise and 58 healthy volunteers （ group C） were enrolled in this study. They were given visual P300 potentials test. Results Compared to group C, latent periods of N1, N2, and P3 of P300 in groups A and B were significantly longer （P 〈 0.01）, and the amplitude of P3 decreased markedly （P 〈 0.01）. Compared to group B, latent periods of N1, N2, and P3 of P300 in group A were significantly longer, and amplitude of P3 decreased markedly （P 〈 0. 01）. Conclusion Visual P300 potentials test has referential meaning in responsible appreciation of schizophrenia by judicial expertise, which needs confirmation by long follow-up.