微波消融对绵羊心肌细胞电生理的影响

本文应用细胞电生理技术观察微波消融后心肌细胞电生理活动的改变，结果显示微波消融后消融灶内细胞坏死，细胞膜电活动消失。消融灶周围细胞跨膜电位异常改变局限于灶外８ｍｍ范围内，其灶外组织损伤范围和程度与射频消融者无显著差异，亦与消融灶大小无关。

Electrophysiological and Pathological Changes Induced by Microwave Ablation in Sheep Myocardium

Electrophysiological and phathological changes in cardiomyocytes induced by microwave ablation were studied in 12 sheeps, There were cell necrosis and loss of electric.activity within the ablation lesion. Abnormal transmembrane potential was observed in surrounding areas limited within 8 mm from the border of ablation lesion. The degree and extent of injury were similar to that induced by radiofrequency ablation. It indicates that the arrhythmogenicity induced by microwave ablation might also be very low. Definite ablation could also be induced by microwave even when the catheter tip was placed 2 mm away from the surface of myocardial tissue. This means that microwave ablation might be efficious for those arrhythmogenic foci which are bigger,deeper and could not be contacted by the catheter tip. Therefore, the use of microwave for ablation may be better than radiofrequency.