| 阿托伐他汀对不稳定性心绞痛患者血清sRAGE和esRAGE水平的影响 |
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| 引用本文： | 李若谷,方唯一,曲新凯,陈晖,杨栓锁,沙慧芳,关韶峰.阿托伐他汀对不稳定性心绞痛患者血清sRAGE和esRAGE水平的影响[J].上海交通大学学报(医学版),2011,31(6):806-808,812. |
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| 作者姓名： | 李若谷 方唯一 曲新凯 陈晖 杨栓锁 沙慧芳 关韶峰 |
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| 作者单位： | 上海交通大学附属胸科医院心内科,上海,200030 |
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| 摘 要： | 目的探讨阿托伐他汀对不稳定性心绞痛患者血清可溶性晚期糖基化终产物受体(SRAGE)和内源性分泌型晚期糖基化终产物受体(esRAGE)水平的影响。方法不稳定性心绞痛患者40例(UA组),给予阿托伐他汀20 mg口服,每日1次,于治疗前和治疗后3个月分别采集静脉血,测量血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、血糖、糖化血红蛋白(HbA1C)、sRAGE及esRAGE水平。另选择20名年龄、性别相匹配的健康体检者作为正常对照组。结果治疗前,UA组的TC和LDL-C水平显著高于正常对照组(P<0.05),sRAGE和esRAGE水平显著低于正常对照组(P<0.05,P<0.01),两组其他指标比较差异均无统计学意义(P>0.05)。经阿托伐他汀治疗3个月后,UA组患者的血糖和HbA1C水平无明显变化(P>0.05),但TC和LDL-C水平明显低于治疗前(P<0.05),sRAGE和esRAGE水平明显高于治疗前(P<0.05);直线相关分析显示,esRAGE水平与LDL-C浓度呈负相关(r=-0.36,P=0.01)。结论他汀类药物具有多效性,阿...
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| 关 键 词： | 阿托伐他汀 不稳定性心绞痛 可溶性晚期糖基化终产物受体 内源性分泌型晚期糖基化终产物受体 |
Effects of atorvastatin on serum levels of sRAGE and esRAGE in patients with unstable angina |
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| LI Ruo-gu,FANG Wei-yi,QU Xin-kai,CHEN Hui,YANG Shuan-suo,SHA Hui-fang,GUAN Shao-feng.Effects of atorvastatin on serum levels of sRAGE and esRAGE in patients with unstable angina[J].Journal of Shanghai Jiaotong University:Medical Science,2011,31(6):806-808,812. |
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| Authors: | LI Ruo-gu FANG Wei-yi QU Xin-kai CHEN Hui YANG Shuan-suo SHA Hui-fang GUAN Shao-feng |
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| Institution: | LI Ruo-gu,FANG Wei-yi,QU Xin-kai,CHEN Hui,YANG Shuan-suo,SHA Hui-fang,GUAN Shao-feng(Department of Cardiology,Shanghai Chest Hospital,Shanghai Jiaotong University,Shanghai 200030,China) |
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| Abstract: | Objective To investigate the effects of atorvastatin on serum levels of soluble receptor for advanced glycation end products(sRAGE) and endogenous secretory receptor for advanced glycation end products(esRAGE) in patients with unstable angina.Methods Forty patients with unstable angina(UA group) were selected,and 20 mg/d of atorvastatin was orally administrated.Venous blood samples were obtained before treatment and 3 months after treatment,and serum total cholesterol(TC),triglyceride(TG),low density lipopr... |
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| Keywords: | atorvastatin unstable angina soluble receptor for advanced glycation end products endogenous secretory receptor for advanced glycation end products |
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