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黄芪对糖尿病大鼠早期肾肥大和蛋白尿的影响
引用本文:徐郁杰.黄芪对糖尿病大鼠早期肾肥大和蛋白尿的影响[J].上海交通大学学报(医学版),1997,17(5):357-359.
作者姓名:徐郁杰
作者单位:上海第二医科大学附属仁济医院肾内科!200001
摘    要:以链脲佐菌素(STZ)诱导大鼠糖尿病模型,观察黄芪单用及与开搏通合用防治早期糖尿病肾病的疗效。结果表明,黄芪能明显降低糖尿病大鼠的血糖、糖化血红蛋白,抑制肾脏肥大,减少尿微量白蛋白排出,黄芪与开搏通合用与黄芪的上述作用相似,其中抑制肾脏肥大作用更明显。提示,黄芪对实验性糖尿病性肾病具有防治作用。

关 键 词:糖尿病肾病  黄芪  肾脏肥大  尿微量白蛋白

Effect of Astragalus Membranaceus on Experimental Diabetic Renal Hypertrophy and Microalbuminuria
Xu Yujie, Zhang Qingyi, Wu Qingwei.Effect of Astragalus Membranaceus on Experimental Diabetic Renal Hypertrophy and Microalbuminuria[J].Journal of Shanghai Jiaotong University:Medical Science,1997,17(5):357-359.
Authors:Xu Yujie  Zhang Qingyi  Wu Qingwei
Abstract:The effects of astragalus, membranaceus (AM) on renal hypertrophy, microalbuminuria, glycemia and HbA1c were studied in experimental diabetic nephropathy induced by streptozotocin in male rats. After eight weeks of AM treatment, the renal hypertrophy and microalbuminuria were suppressed and glycemia and HbA1c decreased. Similar effects were also observed in the group of AM combined with captopril in which renal hypertrophy was reduced even more significantly. The results suggest that AM exerts a beneficial effect on experimental diabetic nephropathy.
Keywords:diabetic nephropathy  astragalus membranaceus  renal hypertrophy  microalbuminuria
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