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常州地区乙型肝炎病毒基因分型及HBV DNA定量的临床研究
引用本文:闵志军,徐培君,张力超,张建伟,何亚琴,王永忠.常州地区乙型肝炎病毒基因分型及HBV DNA定量的临床研究[J].现代实用医学,2009,21(2):99-100.
作者姓名:闵志军  徐培君  张力超  张建伟  何亚琴  王永忠
作者单位:1. 苏州大学医学院,江苏苏州215007;江苏省常州市中心血站,江苏常州,213004
2. 苏州大学医学院,江苏苏州,215007
3. 江苏省常州市中心血站,江苏常州,213004
4. 江苏省常州市第三人民医院,江苏常州,213001
基金项目:江苏省常州市卫生局资助项目 
摘    要:目的了解常州地区乙型肝炎病毒基因型的分布,探讨定量检测HBVDNA的临床意义。方法应用基于膜显色结果判读的DNA芯片检测该地区147例不同HBV感染者HBV基因型,荧光定量PCR(FQ-PCR)法定量测定HBV DNA。结果B型63例(42.86%),C型80例(54.42%),B、C混合型1例(0.68%)、B、D混合型3例(2.04%)。69例慢性乙型肝炎中B型33例、C型34例,63例肝癌患者检出B型15例、C型46例,两组C基因型比率比较差异有统计学意义(P〈0.01)。肝癌患者组B、C型HBV DNA含量(分别为3.58±2.23log10copies/ml和4.82±1.98log10copies/ml)差异有统计学意义(P〈0.05);慢性乙型肝炎患者组HBV DNA含量(分别为5.92±2.38log10copies/ml和6.13±1.49log10copies/ml)差异无统计学意义(P〉0.05)。结论常州地区HBV DNA基因型主要为B型和C型,肝癌患者中C基因型较多,降低病毒载量对治疗可能有积极作用。

关 键 词:肝炎病毒  乙型  基因  病毒  聚合酶链反应

Genotype of Hepatitis B Virus And Clinical Investigation of HBV DNA levels
Min Zhijun,Xu Peijun,Zhang Jianwei,et al..Genotype of Hepatitis B Virus And Clinical Investigation of HBV DNA levels[J].Modern Practical Medicine,2009,21(2):99-100.
Authors:Min Zhijun    Xu Peijun  Zhang Jianwei  
Institution:Medical College of Suzhou University;Suzhou 215007;Changzhou Blood Center;Changzhou 213004
Abstract:Objective To investigate the epidemiological distribution of HBV genotypes in Changzhou area, and to explore the clinical significance of HBV DNA levels. Methods HBV genotypes were detected by gene chips, and HBV DNA was measured by FQ-PCR.Results All 147 samples were positive for HBV DNA. 63 samples were classified as genotype B(42.86%), and 80 samples were classified as genotype C(54.42%). There was 1 case of mixed type of B and C, and there were 3 cases of mixed type of B and D. There were 33 cases of ty...
Keywords:Hepatitis B virus  Genes  viral  Polymerase chain reaction  
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