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淋巴管生成在分化型甲状腺肿瘤的研究进展
引用本文:马捷,周晓军.淋巴管生成在分化型甲状腺肿瘤的研究进展[J].医学研究生学报,2007,20(12):1309-1313.
作者姓名:马捷  周晓军
作者单位:南京大学医学院临床学院(南京军区南京总医院)病理科,江苏南京,210002
基金项目:南京军区南京总医院科研基金
摘    要:甲状腺乳头状癌是最常见的甲状腺恶性肿瘤,其与滤泡性肿瘤(包括滤泡性癌和滤泡性腺瘤)的鉴别诊断目前仍基于形态学观察,尚缺乏可靠的非形态学指标。近年来,随着淋巴管内皮特异性标记物的出现,肿瘤淋巴管形成及其在肿瘤转移中的研究逐渐深入。作者对淋巴管内皮特异性标记物、淋巴管生长因子及其在甲状腺分化型肿瘤中的研究进展作一综述。

关 键 词:淋巴管内皮  血管内皮生长因子  标记物  淋巴道转移
文章编号:1008-8199(2007)12-1309-05
收稿时间:2007-01-23
修稿时间:2007-02-30

Advance of study on lymphangiogenesis in the differentiated thyroid neoplasm
MA Jie,ZHOU Xiao-jun.Advance of study on lymphangiogenesis in the differentiated thyroid neoplasm[J].Bulletin of Medical Postgraduate,2007,20(12):1309-1313.
Authors:MA Jie  ZHOU Xiao-jun
Abstract:Papillary carcinoma is one of the commonest tumors in the thyroid. The pathologic diagnosis of papillary carcinoma as well as follicular carcinoma and follicular adenoma of the thyroid are based on the morphology observation hitherto. However, the diagnostic value of immunostaining for distinction among differentiated neoplasm of the thyroid was so far absent. With the identification of the special markers of lymphatic vessel endothelial cell by immunohistochemical method in the recent years, the rapid progress in the research of lymphangiogenesis of the tumors had been made. This article briefly reviewed the progress of the special markers of lymphatic vessel endothelial cell and vascular endothelial growth factors in the differentiated neoplasm of the thyroid.
Keywords:Lymphatic vessel endothelial cell  Vascular endothelial growth factor  Marker  Lymphatic spread
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