| SD大鼠二氧化氮吸入性肺损伤实验研究 |
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| 引用本文： | 肖永营,夏锡荣,施毅,童茂荣,张希龙.SD大鼠二氧化氮吸入性肺损伤实验研究[J].医学研究生学报,2001,14(1):15-17. |
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| 作者姓名： | 肖永营 夏锡荣 施毅 童茂荣 张希龙 |
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| 作者单位： | 南京军区南京总医院呼吸科 |
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| 摘 要： | 目的：探讨二氧化氮（NO2）吸入性肺损伤的机制。方法：采用实验－对照设计方法，对30只SD大鼠肺组织内丙二醛（MDA）、谷胱甘肽（GSH）、总抗氧化能力（T－AOC）进行比较。结果：NO2吸入组SD大鼠肺组织内MDA值显著高于对照组，而T－AOC值则低于对照组，均有显著意义。只有长期NO2吸入组的SD大鼠GSH值显著低于对照组。结论：SD大鼠吸入NO2后，氧化物质与抗氧化物质失衡所导致的氧化性肺损伤，是肺损伤的重要机制。
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| 关 键 词： | 氧化性 肺损伤 NO2吸入 SD大鼠 实验 |
| 文章编号： | 1008-8199(2001)01-0015-03 |
| 修稿时间： | 2000年5月13日 |
Changes of pulmonary malondialdehyde ,glutathione and total-antioxidation content in SD rat with nitrogen dioxide exposure |
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| XIAO Yong-ying,XIA Xi-rong,SHI Yi,Tong Mao-rong,Zhang Xi-long.Changes of pulmonary malondialdehyde ,glutathione and total-antioxidation content in SD rat with nitrogen dioxide exposure[J].Bulletin of Medical Postgraduate,2001,14(1):15-17. |
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| Authors: | XIAO Yong-ying XIA Xi-rong SHI Yi Tong Mao-rong Zhang Xi-long |
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| Abstract: | Objectives:To evaluate lung injury mechanism in SD rat with nitrogen dioxide(NO 2) exposure. Methods:In the test control study, pulmonary malondialdehyde(MDA),glutathione(GSH) and total antioxidant content(T AOC) were determined in 10 SD rats with long term NO 2 exposure,10 SD rats with short term NO 2 exposure and 10 SD rats with fresh air as control. Results: Pulmonary MDA content was increased and T AOC was decreased significantly in SD rat exposed to NO 2. Pulmonary GSH was decreased significantly in long term NO 2 exposure group as compared with short term NO 2 exposure group and control group. Conclusions: Imbalance between oxidant and antioxidant was an important mechanism in the pathogenesis of oxidizing lung injury in SD rat with NO 2 exposure. |
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| Keywords: | Oxidant Lung injury NO_2 exposure SD rat |
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