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内皮抑素治疗肿瘤的研究进展
引用本文:徐勇飞,朱婵,渠利利,王书奎.内皮抑素治疗肿瘤的研究进展[J].医学研究生学报,2010,23(4):430-434.
作者姓名:徐勇飞  朱婵  渠利利  王书奎
作者单位:南京医科大学附属南京第一医院中心实验室,南京,210006
基金项目:南京市科技局科技发展指导性计划基金(2005指导0584)
摘    要:内皮抑素(endostain,ES)是一种内源性肽段,可抑制内皮细胞生长进而抑制新血管的生成,具有广谱抗肿瘤活性。尽管ES具有较低的毒性、免疫原性和耐受性等优点,但其对于肿瘤治疗的临床试验效果具有争议。文中对ES的来源、结构、作用机制以及现有的治疗策略作一综述。

关 键 词:内皮抑素  作用机制  治疗策略  

Endostatin in tumor therapy: An update
XU Yong-fei,ZHU Chan,QU Li-li,WANG Shu-kui.Endostatin in tumor therapy: An update[J].Bulletin of Medical Postgraduate,2010,23(4):430-434.
Authors:XU Yong-fei  ZHU Chan  QU Li-li  WANG Shu-kui
Institution:Central Laboratory;The First Hospital of Nanjing Affiliated to Nanjing Medical University;Nanjing 210006;Jiangsu;China
Abstract:Endostatin is an endogenous peptide that has been found to inhibit angiogenesis by suppressing the growth of endothelial cells and exhibit a broad-spectrum antitumor activity. Clinical trials using endostatin for the treatment of solid tumors have generated debatable results, albeit with its low toxicity, immunogenicity and resistance. This paper presents an overview of the source, structure and action mechanism of endostatin as well as its related therapeutic strategies.
Keywords:Endostatin  Action mechanism  Therapeutic strategy  
本文献已被 CNKI 维普 万方数据 等数据库收录!
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