| 自身免疫性白内障的晶状体代谢与生理改变研究 |
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| 引用本文： | 张舒,谭长强,罗炎,张晓俊,柯秀峰.自身免疫性白内障的晶状体代谢与生理改变研究[J].医学研究生学报,2003,16(8):577-579. |
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| 作者姓名： | 张舒 谭长强 罗炎 张晓俊 柯秀峰 |
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| 作者单位： | 1. 南京医科大学第二附属医院眼科,江苏南京,210011
2. 东南大学医学院中大医院耳鼻咽喉科,江苏南京,210009 |
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| 基金项目： | 江苏省教育厅自然科学基金资助项目 (批准号 :JW 970 0 95 ) |
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| 摘 要： | 目的 :探讨自身免疫性白内障 (AIC)的病理生理学机制。 方法 :采用酶组织化学方法以及晶状体生理功能检查 ,观察AIC模型动物晶状体生理功能与组织内主要酶活性的变化。 结果 :晶状体组织内Na K ATP酶活性降低与晶状体调节力下降、裂隙灯下显微镜混浊改变之间存在着相关性。 结论 :自身免疫性晶状体损伤 ,进而造成晶状体组织内相关酶代谢异常是AIC的病理基础
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| 关 键 词： | 白内障 自身免疫 酶组织化学 |
| 文章编号： | 1008-8199(2003)08-0577-03 |
| 修稿时间： | 2003年2月10日 |
The lens metabolism and physiology changes in autoimmune cataract of rabbits |
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| ZHANG Shu ,TAN Chang qiang ,LUO Yan ,ZHANG Xiao jun ,KE Xiu feng.The lens metabolism and physiology changes in autoimmune cataract of rabbits[J].Bulletin of Medical Postgraduate,2003,16(8):577-579. |
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| Authors: | ZHANG Shu TAN Chang qiang LUO Yan ZHANG Xiao jun KE Xiu feng |
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| Institution: | ZHANG Shu 1,TAN Chang qiang 2,LUO Yan 1,ZHANG Xiao jun 1,KE Xiu feng 1 |
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| Abstract: | Objectives:The lens metabolism and physiology changes in autoimmune cataract of rabbits were studied. Methods:Ten rabbits (20 eyes) received isologous lens protein antigens (IL Ags) in complete Freund's adjuvant(two times) and incomplete Freund's adjuvant(two times), and then were divided into group A(Autoimmune Cataract, AIC formed) and group B(non AIC formed). Another 5 rabbits (10 eyes) were served as the control group (group C). Physiological functions and enzyme activities of lenses were observed. Results:Following the AIC formation, the activity of Na K ATP ase in lenses of group A was declined, supported by the statistical significance in lens enzyme activity changes between group A and B, group A and C. However, there was no statistical significance between group B and C. Conclusions:There was a close relationship between the AIC formation and lens metabolism changes of rabbits. Therefore, we would assume that the changes of enzyme metabolism in lenses induced by IL Ags is the pathological foundation of AIC. |
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| Keywords: | Cataract Autoimmune disease Enzyme histochemistry |
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