| 核苷类抗乙型肝炎病毒药物耐药的分子机制与体外评价 |
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| 引用本文： | 张岩,白雪帆.核苷类抗乙型肝炎病毒药物耐药的分子机制与体外评价[J].医学研究生学报,2005,18(7):647-649. |
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| 作者姓名： | 张岩 白雪帆 |
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| 作者单位： | 第四军医大学唐都医院解放军感染病诊疗中心,陕西西安,710038 |
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| 摘 要： | 核苷类药物是目前抗乙型肝炎病毒(HBV)的主要药物，但它可引起HBV基因的变异，从而引起耐药。作者就核苷类药物引起变异的特点、产生抗药性的分子机制及体外评价等方面作一综述。
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| 关 键 词： | 乙型肝炎病毒 核苷类药物 耐药分子机制 |
| 文章编号： | 1008-8199(2005)07-0647-03 |
| 修稿时间： | 2004年10月17 |
Evaluation of HBV drug-resistance in vitro and the molecular mechanism of resistance to nucleoside analogue therapy |
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| ZHANG Yan,BAI Xue-Fan.Evaluation of HBV drug-resistance in vitro and the molecular mechanism of resistance to nucleoside analogue therapy[J].Bulletin of Medical Postgraduate,2005,18(7):647-649. |
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| Authors: | ZHANG Yan BAI Xue-Fan |
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| Abstract: | Nucleoside analogues are currently the main drug therapy against HBV infection. However, this type of therapy can cause gene mutations in HBV that result in drug resistance. The types of mutations caused by nucleoside analogues and the molecular mechanism of in vitro drug-resistance were reveiwed. |
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| Keywords: | Hepatitis B virus Nucleoside analogues Molecular mechanism of drug-resistance |
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