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线粒体功能障碍与动脉粥样硬化的发生
引用本文:蔡晓敏,江时森.线粒体功能障碍与动脉粥样硬化的发生[J].医学研究生学报,2007,20(6):660-662.
作者姓名:蔡晓敏  江时森
作者单位:南京军区南京总医院心血管内科,江苏,南京,210002
基金项目:南京军区南京总医院面上课题基金
摘    要:活性氧是动脉粥样硬化血管炎症中多种信号转导系统的主要调节者,贯穿于脂质条纹的形成、病变进展到最终斑块破裂的全过程。线粒体呼吸链是体内活性氧的主要来源,同时也是活性氧的主要靶点,从而导致线粒体功能受损。此外,在无动脉粥样硬化危险因素的线粒体疾病患者中,通常早期即可出现血管并发症。作者就线粒体功能障碍与动脉粥样硬化发生之间的关系作一综述。

关 键 词:线粒体功能障碍  氧化应激  活性氧  动脉粥样硬化
文章编号:1008-8199(2007)06-0660-03
收稿时间:2005-12-05
修稿时间:2005-12-052006-02-27

Mitochondrial dysfunction and atherogenesis
CAI Xiao-min,JIANG Shi-sen.Mitochondrial dysfunction and atherogenesis[J].Bulletin of Medical Postgraduate,2007,20(6):660-662.
Authors:CAI Xiao-min  JIANG Shi-sen
Institution:Department of Cardiology, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu, China
Abstract:Atherosclerosis is a multifactorial disease for which the molecular etiology of many of the risk factors is still unknown.Reactive oxygen species(ROS) mediate various signaling pathways that underlie vascular inflammation in atherogenesis: from the initiation of fatty streak development through lesion progress to ultimate plaque rupture.The mitochondrial respiratory chain is the major source of reactive oxygen species as byproducts of normal cell respiration.Mitochondria may also be important target for reactive oxygen species,which may lead to mitochondrial dysfunction.Moreover,in patients with mitochondrial diseases,vascular complications are commonly observed at an early age,often in the absence of traditional risk factors for atherosclerosis.The aim of this review is to summarize the data linking mitochondrial dysfunction to the pathogenesis of atherosclerosis.
Keywords:Mitochondrial Dysfunction  Oxidative stress  Reactive oxygen species  Atherosclerosis
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