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正电子发射型计算机断层扫描/计算机体层扫描在恶性淋巴瘤临床分期中的初步应用
引用本文:张群,陈龙邦,王靖华,朱虹,耿怀成,褚晓源,管晓翔,宋海珠,金洁.正电子发射型计算机断层扫描/计算机体层扫描在恶性淋巴瘤临床分期中的初步应用[J].医学研究生学报,2007,20(4):394-397.
作者姓名:张群  陈龙邦  王靖华  朱虹  耿怀成  褚晓源  管晓翔  宋海珠  金洁
作者单位:1. 南京军区南京总医院肿瘤内科,江苏南京,210002
2. 南京军区南京总医院核医学科,江苏南京,210002
3. 南京军区南京总医院博士后科研工作站,江苏南京,210002
基金项目:江苏省"六大人才高峰"重点课题
摘    要:目的:观察氟去氧葡萄糖(FDG)正电子发射型计算机断层扫描/计算机体层扫描(PET/CT)显像和传统分期检查方法对恶性淋巴瘤分期和治疗后再分期的影响,以探讨其临床应用价值。方法:采用视觉分析和半定量分析相结合的方法,比较42例病理确诊为恶性淋巴瘤患者传统分期检查和PET/CT对分期和治疗后再分期的符合率,以及对淋巴结区和结外病灶检出率的差异。结果:PET/CT检查与传统分期手段对分期判断的符合率分别为95.2%(40/42)和78.6%(33/42)。对淋巴结内病灶传统分期检查的检出率为88.2%(60/68),PET/CT为97.1%(66/68),两者间差异有显著性意义(P〈0.05);对淋巴结外病灶传统分期检查的检出率为58.3%(14/24),PET/CT为91.7%(22/24),两者间差异有极显著性意义(P〈0.01)。PET/CT检查使TNM分期改变者9例,达21.4%,其中分期升高7例,下降2例,8例(19.0%)的治疗计划发生改变。结论:FDG PET/CT可提高恶性淋巴瘤的分期和再分期的准确率,并可提高淋巴结内外病变的检出率,这有利于更准确地制订治疗方案和预测预后。

关 键 词:淋巴瘤  肿瘤分期  正电子发射计算机断层扫描/计算机体层扫描  氟去氧葡萄糖
文章编号:1008-8199(2007)04-0394-04
修稿时间:2006年10月25

Preliminary application of positron emission tomography/computed tomography on the staging of malignant lymphoma
ZHANG Qun,CHEN Long-bang,WANG Jing-hua,ZHU Hong,GENG Huai-cheng,CHU Xiao-yuan,GUAN Xiao-xiang,SONG Hai-zhu,JIN Jie.Preliminary application of positron emission tomography/computed tomography on the staging of malignant lymphoma[J].Bulletin of Medical Postgraduate,2007,20(4):394-397.
Authors:ZHANG Qun  CHEN Long-bang  WANG Jing-hua  ZHU Hong  GENG Huai-cheng  CHU Xiao-yuan  GUAN Xiao-xiang  SONG Hai-zhu  JIN Jie
Abstract:Objective:Position emission tomography/computed tomography(PET/CT) is a new bio-imaging system which is combined metabolic with anatomic imaging.This study was to compare the accuracy of conventional staging methods(including computed tomography,ultrasound,magnetic resonance imaging,and detection of bone marrow) with that of PET/CT for lymphoma staging and re-staging. Methods:A total of 42 patients with lymphoma diagnosed by operation or biopsy,received conventional and PET/CT staging.The accuracy of these two methods and their impact on lymphoma staging were compared.Results:The accuracy of PET/CT scan was 95.2%(40/42),and that of conventional staging was 78.6%(33/42).The detection rates of internal lymph node were 97.1%(66/68) and 88.2%(60/68),respectively.The detection rates of outer lymph node were 91.7%(22/24) and 58.3%(14/24),respectively.Compared with conventional staging methods,7 cases were up-staged and 2 cases were down-staged by PET/CT,which led to the change of therapy in 8 cases.Conclusion:PET/CT scan is more sensitive and accurate than conventional staging methods in staging and restaging of lymphoma.
Keywords:Lymphoma  Neoplasm staging  Position emission tomography/computed tomography  Fluoredeoxyglucose
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