乳腺癌超声造影特征与诺丁汉预后指数的相关性

目的探讨乳腺癌超声造影增强特征与诺丁汉预后指数（Nottinghamprognosticindex，NPI）的相关性。方法回顾分析91例经手术病理证实的乳腺癌的超声影像特点及微血管成像表现，按NPI的评分分为3组。结果NPI评分3组为：〈3．4分的19例，3．4—5．4的52例，〉5．4的2l例。随着NPI增加，病灶内不均匀性增强、灌注缺损、病灶边缘增强高于中心区增强及增强边界欠清或不清的比例增加，3组间差异有统计学意义（P〈0．05），但增强顺序的类别无统计学意义（P〉0．05）。3组病灶均以“高增强”为主，增强强度3组差异均无统计学意义（P〉0．05）。随着NPI增加，病灶以“早增强”、“慢消退”表现的比例逐渐增多，3组问差异均有统计学意义（P〈0．05）。3组乳腺癌病灶内部微血管构筑模式与NPI评分之间无显著相关（P〉0．05）；病灶内部血管增粗、扭曲及病灶周边微血管呈“毛刺状”、扭曲、增粗随NPI评分增高而出现几率增加，3组问差异均有统计学意义（P〈0．05）。结论乳腺癌超声造影增强特征与NPI评分有一定的相关性，对判断乳腺癌预后有提示作用。

Contrast-enhanced ultrasound features and Nottingham prognostic index in patients with breast cancer

Objective To study the correlation between contrast-enhanced ultrasound （CEUS） features and Nottingham prognostic index （NPI） in patients with breast carcinoma. Methods The ultrasound features and mierovascular imaging manifestation of 91 breast carcinomas confirmed by pathology were retrospectively ana- lyzed. NPI was typically stratified into 3 major groups ： NPI 〈 3.4 （ n = 19 ）, NPI ： 3.4-5.4 （ n = 52 ） and NPI 〉 5.4（n -- 21）. Results With the increase of NPI, the rate of heterogeneous enhancement, perfusion defects, edge enhancement higher than center enhancement, and unclear border increased. The difference among the 3 groups had statistical significance （ P 〈 0. 05 ）. There was no significant difference in enhancement order among the 3 groups （ P 〉 0. 05 ）. The lesions of the 3 groups were mainly ＂high enhancement＂ and there was no signifi- cant difference among the 3 groups （P 〉 0. 05 ）. With the increase of NPI, the rate of early enhancement and late regression increased. The difference among the 3 groups had statistical significance （ P 〈 0. 05 ）. With the in- crease of NPI, the rate of enlarged and twisted vessels as well as peripheral vessel burr increased. There was sig- nificant difference among the 3 groups （P 〈 0. 05 ）. Conclusion CEUS festures and microvescular architecture pattern of breast carcinoma are related to NPI, which is useful in predicating the prognosis of breast carcinoma.