RhoC蛋白在乳腺癌中的表达及临床意义

目的探讨乳腺癌组织中RhoC蛋白的表达及其临床意义。方法采用免疫组织化学方法检测112例乳腺癌、20例癌旁正常组织、15例正常乳腺组织中RhoC蛋白的表达，并对其与临床病理特征的关系进行分析，同时检测乳腺癌组织中CD34的表达，计算微血管密度（MVD），并分析其与RhoC蛋白的相关性。结果RhoC蛋白在乳腺癌组织中的阳性表达率为40．2％，而在癌旁乳腺组织及正常乳腺组织中不表达，其在乳腺癌组织中的表达与淋巴结转移和病理分期相关（P〈0．05）；乳腺癌组织中RhoC蛋白阳性患者MVD值显著高于阴性者，差异有统计学意义（P〈0．05）。结论RhoC蛋白表达与乳腺癌的淋巴结转移、病理分期及MVD信相关． 其表达上调可能促进了乳腺癌的侵袭、转移过程。

Expression and clinical significance of RhoC protein in breast cancer

Objective To investigate the expression and clinical significance of RhoC protein in breast cancer. Methods Expression of RhoC protein was detected by immunohistochemistry in 112 cases of breast cancer, 20 cases of adjacent non-cancerous normal tissues and 15 cases of normal mammary gland tissues. The relation between expression of RhoC protein and clinieopathological characteristics was analyzed. Expression of CD34 in breast cancer tissues was detected. Microvessel density （MVD） was calculated and its correlation with RhoC protein was analyzed. Results RhoC had a positive expression rate of 40. 2% （45/112） in breast cancer, while it was not expressed in adjacent non-cancerous tissues or normal mammary gland tissues. RhoC expression in breast tissues was related to lymph node metastasis and pathological stages （ P 〈 0.05 ）. MVD value in patients with positive RhoC expression was significantly higher than that in patients with negative RhoC expression （ P 〈 0. 05 ）. Conclusions The expression of RhoC protein is related to lymphatic metastasis, pathological stages and MVD value. The upregulation of RhoC protein expression may promote the metastasis and invasion of breast cancer.