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血清HER2/neu在HER2过表达型乳腺癌新辅助化疗中的变化及意义
引用本文:姚宇锋,马蓉,龚建平,秦建伟,唐金海.血清HER2/neu在HER2过表达型乳腺癌新辅助化疗中的变化及意义[J].内分泌外科杂志,2013(5):368-370,383.
作者姓名:姚宇锋  马蓉  龚建平  秦建伟  唐金海
作者单位:[1]江苏省肿瘤医院普外科,210009 [2]江苏省肿瘤医院科研科,210009
基金项目:江苏省第四期"333工程"科研项目资助(BRA201114)
摘    要:目的 探讨在人表皮生长因子受体2(human epidermal growth factor receptor2,HER2)过表达型乳腺癌新辅助化疗中血清HER2/neu浓度的变化及其与疗效的相关性.方法 采用酶联免疫法检测78例HER2过表达型局部进展期乳腺癌患者新辅助化疗前后血清HER2/neu的浓度,分析其变化与新辅助化疗疗效的相关性.结果 HER2过表达型乳腺癌患者新辅助化疗前后血清HER2/neu的浓度分别为(18.6±10.0) ng/ml,(11.6±6.1)ng/ml,前后比较差异有统计学意义(P <0.001).新辅助化疗前后血清HER2/neu浓度变化与化疗疗效相关(P =0.029).新辅助化疗前后血清HER2/neu浓度变化与病理完全缓解相关(P<0.05).结论 在HER2过表达型乳腺癌患者中,新辅助化疗前后血清HER2/neu浓度变化可作为预测化疗疗效的指标.

关 键 词:乳腺肿瘤  血清HER2  neu  新辅助化疗

The clinical significance of the change of serum HER2/neu concentration during neoadjuvant chemotherapy of the HER2-overexpressed breast cancer
Authors:YAO Yu-feng  MA Rong GONG Jian-ping  QIN Jian-wei  TANG Jin-hai
Institution:1.Department of General Surgery, Jiangsu Cancer Hospital, Nanjing 210009, China;)
Abstract:Objective To explore the change of serum HER2/neu concentration during neoadjuvant chemotherapy for HER2-overexpressed breast cancer and its correlation with the response to the neoadjuvant chemotherapy.Methods The concentration of the serum HER2/neu in 78 cases of HER2-overexpressed advanced breast cancer treated with neoadjuvant chemotherapy were detected with enzyme-linked immunosordent assay(ELISA).The relationship between the serum HER2/neu concentration and the response of neoadjuvant chemotherapy was analyzed.Results The serum HER2/neu concentration of befor and after neoadjuvant chemotherapy was 18.6 ± 10.0ng/ml,11.6 ± 6.lng/ml respectively.The serum HER2/neu concentration decreased significantly(P < 0.001).The response of neoadjuvant chemotherapy was correlated with the change of the serum HER2/neu concentration.The pathologic complete response was correlated with the serum HER2/neu concentration of prechemotherapy and the change of the serum HER2/neu concentration.Conclusion The change of serum HER2/neu concentration may serve as a marker predicting the response of neoadjuvant chemotherapy in HER2-overexpressed breast cancer.
Keywords:Breast neoplasm  Serum HER2/neu  Neoadjuvant chemotherapy
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