| 硝酸士的宁对刺激鲫鱼脊髓诱发的Mauthner细胞胞内电位变化的影响 |
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| 引用本文： | 虞棻,童学红,李博,刘丽敏,张茂先,李效义.硝酸士的宁对刺激鲫鱼脊髓诱发的Mauthner细胞胞内电位变化的影响[J].实验动物与比较医学,2008(6). |
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| 作者姓名： | 虞棻 童学红 李博 刘丽敏 张茂先 李效义 |
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| 作者单位： | 首都医科大学生理学系; |
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| 摘 要： | 目的 探索肌注硝酸士的宁对刺激鲫鱼脊髓所诱发的M细胞胞内电位变化的影响.方法 运用微电极穿刺技术记录M细胞的胞内电位变化.结果 肌注硝酸士的宁后逆向动作电位后突触后电位(PsPa)的幅度升高,持续时间增加,并可在此基础上暴发动作电位.结论 从脊髓到M细胞的传人通路中可能有抑制性递质甘氨酸的释放和相应受体的存在,其与兴奋性递质一起调节M细胞兴奋性,从而使M细胞的活动与整体一致.
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| 关 键 词： | Mauthner细胞 士的宁 突触后电位 鲫鱼 |
Effects of Intramuscular Injection of Strychnine on the Intracellular Potential Changes of Mauthner Cells Evoked by Spinal Cord Stimulation in Crucian Carps |
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| YU Fen,TONG Xue-hong,LI Bo,LIU Li-min,ZHANG Mao-xian,LI Xiao-yi.Effects of Intramuscular Injection of Strychnine on the Intracellular Potential Changes of Mauthner Cells Evoked by Spinal Cord Stimulation in Crucian Carps[J].Laboratory Animal and Comparative Medicine,2008(6). |
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| Authors: | YU Fen TONG Xue-hong LI Bo LIU Li-min ZHANG Mao-xian LI Xiao-yi |
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| Institution: | YU Fen,TONG Xue-hong,LI Bo,LIU Li-min,ZHANG Mao-xian,LI Xiao-yi(Department of Physiology,Capital Medical University,Beijing 100069,China) |
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| Abstract: | Objective To explore the intracellular potential changes of Mauthner cells(M-cells)evoked by spinal cord stimulation in the Crucian carp after intramuscular injection of strychnine.Methods\ Microelectrode recording technique was used to explore the electrophysiological properties of M-cells.Results\ Both the amplitude and the average duration of the postsynaptic potential(PSP) in M-cells were increased,and two or more action potentials were sometimes superimposed.Conclusion\ The results suggest that there a... |
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| Keywords: | Mauthner cell Strychnine PSPs Crucian carp |
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