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超容量负荷联合压力负荷制备家兔心衰模型的可行性探讨
引用本文:邹操,刘志华,赵彩明,蒋彬,宋建平,杨向军,蒋廷波,杨俊华,蒋文平.超容量负荷联合压力负荷制备家兔心衰模型的可行性探讨[J].实验动物与比较医学,2005,25(4):211-214.
作者姓名:邹操  刘志华  赵彩明  蒋彬  宋建平  杨向军  蒋廷波  杨俊华  蒋文平
作者单位:苏州大学附属第一医院心内科,苏州,215006
基金项目:江苏省自然科学基金(编号BK2005034).
摘    要:目的 探讨超容量负荷联合压力负荷建立家兔心衰模型的可行性。方法 22只家兔随机分为两组:心衰组11只和假手术组11只;先诱导主动脉瓣关闭不全,2周后腹主动脉缩窄,制造超容量负荷及压力负荷,利用心导管术和心脏多谱勒观察术前后家兔血流动力学及心脏结构和功能的变化。结果 (1)心衰组术后主动脉收缩压、脉压、左室舒张末压较术前及假手术组明显增加(P〈0.01);(2)心衰组术后左房内径、室间隔厚度、左室收缩和舒张末径明显增加(P〈0.01),射血分数及左室缩短率明显降低(P〈0.01);(3)心衰组左室/体重比、肺脏/体重比明显高于假手术组(P〈0.01)。结论 超容量负荷结合压力负荷建立心衰模型方法可行,心衰形成时间短,重复性好,且成功率较高,符合人类慢性心衰发展过程。

关 键 词:心力衰竭  动物模型  压力负荷  容量负荷
文章编号:1004-8448(2005)04-0211-04
收稿时间:2005-07-13
修稿时间:2005年7月13日

A Model of Heart Failure Induced by Volume Plus Pressure Overload in Rabbits
ZOU Cao,LIU Zhi-hua,ZHAO Cai-ming,JIANG Bin,SONG Jian-ping,YANG Xiang-jun,JIANG Ting-bo,YANG Jun-hua,JIANG Wen-ping.A Model of Heart Failure Induced by Volume Plus Pressure Overload in Rabbits[J].Laboratory Animal and Comparative Medicine,2005,25(4):211-214.
Authors:ZOU Cao  LIU Zhi-hua  ZHAO Cai-ming  JIANG Bin  SONG Jian-ping  YANG Xiang-jun  JIANG Ting-bo  YANG Jun-hua  JIANG Wen-ping
Institution:Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Abstract:Objective To establish animal model of heart failure induced by volume plus pressure overload in rabbits. Methods Twenty-two rabbits were divided into two groups: 11 rabbits with heart failure and 11 sham-operated animals. We first obtained a volume overload by creation of an aortic insufficiency, which was followed 14 days later by pressure overload induced by constricting the abdominal aorta. The homodynamic parameters and cardiac structure and function were detected via catheterization and echocardiography respectively 6 weeks later. Results (1) Aortic systolic pressure, pulse pressure, left ventricular end diastolic pressure of heart failure rabbits were significantly increased compared with sham-operated rabbits (P<0.01). (2) The left atria diameter, left inter-ventricular septum, left ventricular end diastolic and systolic diameter were also increased markedly in heart failure rabbits, but their ejection fraction and left ventricular shorten fraction were decreased (P<0.01). (3)In heart failure rabbits, the ratio of left ventricular mass and pulmonary mass to body weight were higher than that in sham-operated rabbits (P<0.01). Conclusion Animal model of heart failure were established by volume plus pressure overload in rabbits successfully, with short time, better repetition and higher rate of success, according with the development of human heart failure.
Keywords:Heart failure  Animal model  Pressure overload  Volume overload
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