| 《实验动物与比较医学》第25卷第1～4期总目次 |
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| 引用本文： | 巴晓红,齐志敏,李艳芹.《实验动物与比较医学》第25卷第1～4期总目次[J].实验动物与比较医学,2005,25(4):253-256. |
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| 作者姓名： | 巴晓红 齐志敏 李艳芹 |
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| 作者单位： | 锦州医学院附属第三医院神经科 锦州121001(巴晓红)，锦州医学院药理教研室 锦州121001(齐志敏)，锦州医学院电镜室 锦州121001(李艳芹) |
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| 摘 要： | ·主编寄语· 抚前瞻后，大力发展我国比较医学—写于本刊更名之际··························，····································……刘瑞三(67) ·学者论坛· 对中闺实验动物科学事业儿个问题的浅见(续).·································································……徐兆光，刘瑞三(3) 如何开展外科比较医学研究·····，····························…
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| 关 键 词： | 氧吸入疗法 缺氧缺血 脑 再灌注损伤 |
| 收稿时间： | 2005/4/1 0:00:00 |
| 修稿时间： | 2004/7/15 0:00:00 |
The Protective Action of Oxygen-Breathing Pretreatment against Brain Ischemia-Reperfusion Injury in Rats |
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| BA Xiao-hong,QI Zhi-min,LI Yan-qin.The Protective Action of Oxygen-Breathing Pretreatment against Brain Ischemia-Reperfusion Injury in Rats[J].Laboratory Animal and Comparative Medicine,2005,25(4):253-256. |
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| Authors: | BA Xiao-hong QI Zhi-min LI Yan-qin |
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| Institution: | BA Xiao-hong1,QI Zhi-min2,LI Yan-qin3 |
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| Abstract: | Objective To investigate the protective action of oxygen-breathing pretreatment against brain ischemia-reperfusion injury in rats. Methods Using a model of focal brain ischemia-reperfusion in Sprague-Dowley rats, SOD activity and MDA level measurement, electron microscopy and neurological functional examination were performed to evaluate the protective role of oxygen-breathing pretreatment. Results Oxygen-breathing pretreatment showed a protective effect on brain ischemia-reperfusion injury. It presented significantly increased SOD level and decreased content of MDA. The ultrastructure of neurons in rats of oxygen-breathing pretreated group was ameliorated effectively. Conclusions Oxygen-breathing pretreatment has protective effect against brain ischemia-reperfusion injury. |
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| Keywords: | Oxygen-Inhalation Therapy Hypoxia-ischemia brain Reperfusion injury |
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