| 运用人癌裸小鼠移植瘤模型进行抗癌新药评价—NCI和EORTC临床前体内药效学研究方法和原则 |
| |
| 引用本文： | 陈陵际 丁健 等. 运用人癌裸小鼠移植瘤模型进行抗癌新药评价—NCI和EORTC临床前体内药效学研究方法和原则[J]. 实验动物与比较医学, 2001, 21(4): 247-250 |
| |
| 作者姓名： | 陈陵际 丁健 等 |
| |
| 作者单位： | 中国科学院上海药物研究所,上海,200031 |
| |
| 基金项目： | 北京市科学技术委员会专项资金资助项目(954981500) |
| |
| 摘 要： | 人癌裸小鼠移植瘤模型是抗癌新药评价的必要工具，本文综述了人癌移植瘤模型的建立标准和NCI、EORTC运用这些模型进行抗癌新物质体内评价的原则、方法和注意点。
|
| 关 键 词： | 人癌模型 实验治疗 裸小鼠 移植瘤 抗癌新药 药效评价 NCI EORTC |
| 文章编号： | 1004-8448(2001)04-0247-04 |
| 修稿时间： | 2001-01-08 |
The Criteria of New Anticancer Agents Evaluation in Human Tumor Nude Mice Model--The preclinical criteria of NCI and EORTC investigation |
| |
| CHEN Ling-ji,DING Jian. The Criteria of New Anticancer Agents Evaluation in Human Tumor Nude Mice Model--The preclinical criteria of NCI and EORTC investigation[J]. Laboratory Animal and Comparative Medicine, 2001, 21(4): 247-250 |
| |
| Authors: | CHEN Ling-ji DING Jian |
| |
| Abstract: | Recent years, in spite of all its limitations and high expenses, the nude mouse-human tumor model has become more frequently applied to the evaluation of new compounds and pre-clinical research. We reviewed briefly the pre-clinical criteria of NCI and EORTC investigation in this paper, and hope to consult for researchers in our country. |
| |
| Keywords: | Human tumor models Experimental therapy Nude mice |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《实验动物与比较医学》浏览原始摘要信息 |
|
点击此处可从《实验动物与比较医学》下载全文 |
