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老年性痴呆动物模型研究进展及其评价
引用本文:谢宁,宋琳莉,牛英才,汪淼,计仁军,代晓光.老年性痴呆动物模型研究进展及其评价[J].实验动物与比较医学,2006,26(1):50-53.
作者姓名:谢宁  宋琳莉  牛英才  汪淼  计仁军  代晓光
作者单位:黑龙江中医药大学中医基础诊断教研室,哈尔滨,150040
摘    要:老年性痴呆(Alzheimer's disease,AD)是一种与年龄相关的中枢神经系统退行性病变。由于至今其病因不明、发病机制复杂,制约了该病动物模型的制作研究工作。本文对各类AD动物模型的研究进展及其优劣进行了评价,认为Tg2576转基因小鼠已成为较合适的防治AD新药研究的动物模型。

关 键 词:老年性痴呆  动物模型  转基因
文章编号:1004-8448(2006)01-0050-04
收稿时间:2005-01-24
修稿时间:2005-11-29

Advances and Evaluation on Research of Animal Models of Alzheimer's Disease
XIE Ning,SONG Lin-li,NIU Ying-cai,WANG Miao,JI Ren-jun,DAI Xiao-guang.Advances and Evaluation on Research of Animal Models of Alzheimer''''s Disease[J].Laboratory Animal and Comparative Medicine,2006,26(1):50-53.
Authors:XIE Ning  SONG Lin-li  NIU Ying-cai  WANG Miao  JI Ren-jun  DAI Xiao-guang
Institution:Heilongjiang University of Chinese Medicine, Harbin 150040, China
Abstract:AD is a kind of age-related degeneration disease in nervous system .The research of animal models of Alzheimer's disease is restrictive because it's cause isn't clear and etiopathogenesis The authors reviewed and evaluated various kind of AD animal models and concluded that the Tg2576 mice had been a suitable animal model for testing of novel anti-AD drugs.
Keywords:Alzheimer's disease  Animal models  Transgenic animal
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