实验用五指山小型猪选育

目的培育符合生物医学研究需要、标准化程度高的实验用五指山小型猪。方法常规遗传育种技术与现代遗传育种技术相结合，对现有五指山小型猪资源进一步选育和实验动物标准化研究，以建立遗传多样性丰富的封闭群和基因纯合度高的近交系。结果利用我国特有的五指山小型猪资源及其已有的保种选育成果，在保持其体小特性的前提下，在封闭群引种群遗传多样性丰富，近交选育群引种群基因纯合度高的基础上，形成实验用封闭群和两个近交选育群。结论形成的封闭群和近交选育群保持了体型矮小的特性，标准化程度提高，生理、生化、遗传等生物学特性稳定，生产繁殖性能较高，具有广泛的环境适应性，是理想的实验动物资源，可满足多种研究领域的需要，有着重要的应用价值和广阔的发展前景。

Selection and Breeding of Experimental Wuzhishan Minipigs

Objective To establish the closed colony and inbred strains of Wuzhishan Minipigs （WZSP）. Methods For the purposes of establishing closed colony with genetic diversity and inbred strains with high homozygous genes, traditional breeding techniques and modem molecular genetic technology were employed for the seed selection and standardization of experimental WZSP. Results Under the premise of maintaining small size, one closed colony and two inbred strains of WZSP were fostered from those introduced outbred WZSP with rich genetic diversity and inbred WZSP with high genetic homogeneity. At the same time, the databases of biological properties of the established WZSP strains were created. Conclusion The newly established outbred and inbred WZSP strains, which maintained small size, steady physiological, biochemical, genetic parameters, and high productive performance, were proved to be ideal laboratory animals＇with a wide range of environmental adaptability. The WZSP strains would meet the needs of a variety of research areas and have potential application value and broad prospects.