| 不同免疫状态的小鼠对禽流感病毒H5N1感染的敏感性及其机制探讨 |
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| 引用本文： | 占玲俊,李枫棣,吕琦,朵建英,鲍琳琳,邓巍,马春梅,许黎黎,秦川.不同免疫状态的小鼠对禽流感病毒H5N1感染的敏感性及其机制探讨[J].实验动物与比较医学,2012(2):78-82. |
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| 作者姓名： | 占玲俊 李枫棣 吕琦 朵建英 鲍琳琳 邓巍 马春梅 许黎黎 秦川 |
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| 作者单位： | 卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021;卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021;卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021;卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021;卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021;卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021;卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021;卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021;卫生部人类疾病比较医学重点实验室;国家中医药管理局人类疾病动物模型三级实验室;中国医学科学院医学实验动物研究所,北京100021 |
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| 摘 要： | 目的比较不同免疫状态的小鼠对禽流感病毒的易感性,并探讨可能的原因。方法四种免疫状态的小鼠,无菌BALB/c小鼠,SPF级BALB/c小鼠,SCID小鼠和nude小鼠,以10 TCID50的禽流感病毒50 μL感染小鼠,观察小鼠的体重变化,存活率,各组织脏器的病毒分布,肺组织的细胞因子变化和肺组织病理病变。结果四种小鼠均能感染禽流感病毒,其中,无菌小鼠对禽流感病毒H5N1的易感性最低,存活率最高。并且病毒在无菌鼠体内病毒的复制水平最低,细胞因子TNF-α,IL-12,MIP2,GATA3,IFN-a/β在感染后表达水平最低,其中第7天最低。结论无菌小鼠能感染禽流感病毒,但是相比较SPF级BALB/c小鼠,SCID小鼠和nude小鼠,其易感性最低,可能与病毒在组织内的低复制和细胞因子的低表达均有关。
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| 关 键 词： | 禽流感病毒H5N1 易感性 病毒复制 细胞因子 小鼠品系 |
Susceptibility of mice strains in different immune status to avian influenza virus H5N1 infection and the possible mechanism |
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| ZHAN Ling-jun,LI Feng-di,LV Qi,DUO Jian-ying,BAO Lin-lin,DENG Wei,MA Chun-mei,XU Li-li and QIN Chuan.Susceptibility of mice strains in different immune status to avian influenza virus H5N1 infection and the possible mechanism[J].Laboratory Animal and Comparative Medicine,2012(2):78-82. |
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| Authors: | ZHAN Ling-jun LI Feng-di LV Qi DUO Jian-ying BAO Lin-lin DENG Wei MA Chun-mei XU Li-li and QIN Chuan |
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| Institution: | Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China;Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China;Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China;Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China;Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China;Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China;Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China;Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China;Key Laboratory of Human Disease Comparative Medicine,Ministry of Health;Key Laboratory of Human Diseases Animal Models,State Administration of Traditional Chinese Medicine;Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences CAMS, Beijing 100021,China |
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| Abstract: | |
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| Keywords: | Avian influenza virus H5N1 Susceptibility Virus replication Cytokine Mouse strains |
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