黑色素相关研究中动物模型的应用进展

目的测定和比较分析WHBE兔、日本大耳白兔、新西兰白兔血液学生化指标，揭示WHBE兔血液生化学特性。方法选择WHBE兔、日本大耳白兔、新西兰白兔各40只，雌雄各半，耳中央动脉采血，应用日立7020全自动生化仪测定27项血液生化指标。结果①性别因素对WHBE兔的Ca、P、CHOL、HDL．C、LDL—C、FMN六项指标存在着显著差异（P〈0．05，P〈0．01）：②与日本犬耳白兔和新西兰白兔比较，WHBE兔的部分血液生化指标与日本大耳白兔和新西兰兔存在显著差异，可能与WHBE兔的特性有关；③与人类血液生化参数比较，WHBE兔除CHOL、HDL—C、LDL—C、UA、CK、CK—MB与人类有显著差异外，其它指标均于人类接近。结论WHBE兔可能适合于作为研究人的部分血液生化值变化和代谢模型的实验动物。

Application of Animal Models in Melanin-Related Studies

Objective To comparative analysis of blood biochemical indexes in WHBE rabbits, Japanese White rabbits and New Zealand White rabbits, and further reveal on blood biochemical characteristics of WHBE rabbits. Methods Fourty in each of WHBE rabbits, Japanese White rabbits and New Zealand White rabbits, half male and female, the blood was sampled from the central artery of ear for testing the blood biochemical indexes. Results （1） Gender factor has significant influences on serum Ca, P, CHOL, HDL-C, LDL-C, FMN indexes in WHBE rabbits （P〈0.05, P〈0.01）; （2） Compared with Japanese White rabbits and New Zealand White rabbits, partly blood biochemical indices had significant differences between WHBE rabbit and Japanese White rabbits or between WHBE rabbit and New Zealand White rabbits, those maybe related with itself characteristics;（3）CHOL, HDL-C, LDL-C, UA, CK and CK-MB were obviously exist with differences between human being and WHBE rabbit, and the other biochemical indexes were similar to those of human being. Conclusion The WHBE rabbits may be used for research on partly change of biochemical indices and metabolism diseases in human.