辛伐他汀对老年高血压伴高脂血症踝臂指数和脉搏波传导速度的影响

目的:探讨辛伐他汀对老年高血压伴高脂血症患者踝臂指数(anklebrachialindex,ABI)和脉搏波传导速度(pulse wave velocity,PWV)的影响。方法:选择85例老年高血压伴高脂血症患者,随机分为对照组40例和辛伐他汀组45例,治疗3个月,观察治疗前后血脂、血压、PWV、ABI的变化。结果:治疗组血清总胆固醇、低密度脂蛋白胆固醇、甘油三酯较治疗前明显降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)明显升高。两组患者治疗后收缩压(SBP)、舒张压(DBP)和脉压(PP)较治疗前均有不同程度的降低(P<0.05)。与对照组治疗后相比,治疗组SBP、PP减少(P<0.05)。两组患者治疗后PWV较治疗前减少,ABI较治疗前增加((P<0.05);与对照组治疗后相比,治疗组ABI增加的程度更加明显(P<0.05)。结论:辛伐他汀可减少老年高血压伴高脂血症患者PWV,缩小脉压,增加ABI,改善外周血管功能。

Effects of simvastatin on pulse wave velocity and ankle-brachial index in geriatric hypertensive patients with hyperlipemia

Objective：To observe the effect of simvastatin on pulse wave velocity （PWV） and ankle-brachialindex （ABI） in geriatric hypertensive patients with hyperlipemia. Methods： Eighty five patients with hypertension-hyperlipemia were randomly divided into control group （ n = 40 ） and simvastatin group （ n = 45 ） , which were treated for 3 months. Systolic blood pressure （ SBP ） , diastolic blood pressure（DBP）, pulse pressure （PP）, blood fat, PWV and ABI were measured before and after treatment. Results： Serum total cholesterol （TC） ,low density lipoprotein cholesterol （ LDL-C ） and triglyceride （TG） in patients with simvastatin group were more decrease, and high-density lipoprotein cholesterol （HDL-C） was more increase. The levels of SBP, DBP and PP were markedly depressed in The both two groups, but compared with control group, the degrees of decrease of SBP, PP were more. In addition, the PWV were more visibly decreased and ABI increased after treatment than before treatment in two groups. However, compared with control group, the degree of increase in ABI with simvastatin group was more visibly. Conclusions：Simvastatin may improve the vascular function through decreaseing PWV,reducing PP and increasing ABI in geriatric hypertensive patients with hyperlipemia.