FTO基因的单核苷酸多态性对腹腔镜Roux-en-Y胃旁路手术疗效的影响

目的研究FTO基因的单核苷酸多态性对肥胖病人腹腔镜Roux-en-Y胃旁路手术疗效的影响。方法选取肥胖病人60例，实施腹腔镜Roux-en-Y胃旁路手术。记录术前、术后1、3、6、12个月的体质量指数（BMI），并测定血清空腹葡萄糖（FPG）、餐后2小时血糖（2hPG）。并检测病人FTO基因的单核苷酸多态性。结果检出存在TT、TA、AA 3种种基因型，分别为TT 46例（76.67%），TA 13例（21.67%），AA 1例（1.67%）。由于AA个体数量较少，和TA合并进行统计分析（AA+TA组）。AA+TA组与TT组病人在性别、年龄、术前及术后各时间点BMI、FBG差异无统计学意义（P>0.05）。TA+AA组在术前、术后3个月2hPG显著高于TT组（P < 0.05），而术后6个月、12个月2hPG差异无统计学意义（P>0.05）。结论对于rs9939609 A等位基因的病人存在潜在2型糖尿病的可能，无论血糖是否正常都应当实施腹腔镜Roux-en-Y胃旁路手术；而rs9939609 T等位基因的单纯肥胖病人可以实施袖状胃切除。

Effect of single-nucleotide polymorphism of the FTO gene on laparoscopic Roux-en-Y gastric bypass

ObjectiveTo explore the effects of single-nucleotide polymorphism of the FTO gene on laparoscopic Roux-en-Y gastric bypass.MethodsSixty fat patients were treated with the laparoscopic Roux-en-Y gastric bypass.The body mass index(BMI), serum fasting plasma glucose(FPG) and blood glucose at 2 hours after meal(2hPG) before operation, and after 1, 3, 6 and 12 months of operation were measured, and recorded, and the single-nucleotide polymorphism of FTO gene were detected in all cases.ResultsThe TT(46 cases, 76.67%), TA(13 cases, 21.67%) and AA(1 case, 1.67%) genotypes were identfied.Due to the small number of AA individuals, the AA group and TA group was put together for analyzing.The differences of the sex, age, BMI and FBG at preoperative and postoperative time points were not statistically significant between two groups(P>0.05).The 2hPG in TA+AA group before operation and postoperative 3 months were significantly higher than that in TT group(P < 0.05), while the differences of 2hPG between two groups after 6 and 12 months of operation were not statistically significant(P>0.05).ConclusionsThe potential type 2 diabetes patients may exists the rs9939609 A allele, the laparoscopic Roux-en-Y gastric bypass should be implemented regardless of whether their blood glucose is normal, and the sleeve gastrectomy in simple obesity patients with rs9939609 T allele may be performed.