三磷腺苷对全身麻醉苏醒拔管期心血管反应的影响

目的:观察三磷腺苷(ATP)对全身麻醉(全麻)苏醒拔管期心血管反应的影响.方法:选择ASA Ⅰ～Ⅱ级全麻手术患者40例,随机分为观察组和对照组,每组各20例.观察组于术毕拔管前5 min缓慢静脉注射ATP 0.3 mg/kg,对照组拔管期不用任何药物,记录拔管前5 min、拔管时、拔管后1、3、6 min各时点的收缩压...

Effects of triphosadenine on preventing cardiovascular responses during extubation awakening period after general anesthesia

Objective：To observe the effects of triphosadenine（ATP） on preventing cardiovascular responses to endotracheal extubation when a patient came to his consciousness from general anesthesia.Methods：Forty patients（ASA Ⅰ toⅡ） undergone general anesthesia were randomly allocated to observation and control group with 20 cases in each.The patients in observation group were given intravenous drip with ATP at a dose of 0.3 mg/kg 5 min prior to extubation,whereas the patients in control group were received no medication.Systolic blood pressure（SBP）,diastolic blood pressure（DBP）,heart rate（HR） and mean arterial pressure（MAP） were recorded at 5 min before extubation,during extubation,at 1,3 and 6 min after extubation,and RPP was determined.Results：The indexes at 5 min before extubation in the two groups showed no significant difference（P0.05）.There were no significant differences in SBP,DBP,MAP and HR between 5 min before extubation and during extubation,at 1,3 and 6 min after extubation in observation group（P0.05）,and RPP was increased only in extubation time（P0.05）.Compared with 5 min before extubation,all indexes were significantly increased during extubation,at 1 min after extubation in control group（P0.05-P0.01）,and the value of SBP,MAP,HR and RPP were significantly increased at 3 min after extubation,too（P0.05-P0.01）.All indexes at 6 min after extubation were similar to the level 5 min before extubation in control group（P0.05）.All indexes in observation group were significantly decreased during extubation,at 1 min and 3 min after extubation compared with control group（P0.05-P0.01）.Conclusions：ATP can prevent patients from cardiovascular response effectively when patients are in condition of extubation in palinesthesia.