氟比洛芬与奈福泮用于自控静脉镇痛效果比较

目的：比较氟比洛芬酯与奈福泮用于自控静脉镇痛（patient-controlled intravenous analgesia,PCIA）的临床效果。方法：择期全麻手术90例（腹部和开胸手术）,随机分成3组,每组30例。A组：氟比洛芬100mg＋芬太尼0.35mg;B组：氟比洛芬100mg;C组：盐酸奈福泮100mg＋芬太尼0.35mg。3组均用0.9%NaCl稀释至100ml。A组和B组在全麻插管后即静脉注射（静注）氟比洛芬酯50mg,C组在手术结束前10min静注盐酸奈福泮20mg。参数设定：持续输注量为2ml/h,PCIA为2ml,锁定时间10min。所有患者术毕静注恩丹西酮4mg。观察术后2h、4h、8h、16h、24h、36h的视觉模拟镇痛评分（VAS）和相关的不良反应,记录36h内PCIA按压次数,调查PCIA的基本满意度。结果：所有患者均即时清醒拔管。A组在各时段VAS和按压总次数均显著低于B、C组（P〈0.01）,B组与C组差异无统计学意义（P〉0.05）。不良反应中咽喉痛和精神症状C组显著高于A组和B组（P〈0.01）,而A组与B组差异无统计学意义（P〉0.05）;A组满意度显著高于B组和C组。结论：氟比洛芬与盐酸奈福泮均可行PCIA;在复合同等小剂量芬太尼时,氟比洛芬效果更加满意,不良反应发生率少,值得临床推广。

Comparison of effects between furbiprofen and nefopam in patient-controlled intravenous analgesia

Objective:To compare the clinical effects between furbiprofen and nefopam in patient-controlled intravenous analgesia(PCIA).Methods:Ninety patients with selective general anesthesia were randomly divided into three groups:Group A(n=30)was given 100 ml mixture solution of furbiprofen 100 mg,fentanyl 0.35mg and 0.9% NaCl;Group B(n=30)was given 100 ml mixture solution of furbiprofen 100 mg and 0.9% NaCl;Group C(n=30)was given 100 ml mixture solution of nefopam 100 mg,fentanl 0.35 mg and 0.9% NaCl.The patients ...