阿奇霉素联合维生素D治疗儿童哮喘疗效观察

目的:探讨阿奇霉素联合维生素D治疗儿童哮喘的临床疗效。方法:选取儿童支气管哮喘患者90例,随机分为常规治疗组(A组)、阿奇霉素+常规治疗组(B组)和阿奇霉素联合维生素D+常规治疗组(C组)。所有患儿治疗前后均测定血清中白细胞介素(IL)-2、IL-17浓度,比较3组患儿治疗前后血液指标变化、症状体征好转时间及住院时间。结果:3组患儿治疗前血清IL-2和IL-17水平差异无统计学意义(P>0.05);治疗后3组患儿血清IL-2水平均较治疗前升高、IL-17水平降低(P<0.01),其中C组改变更为明显(P<0.05～P<0.01);C组均较A组、B组症状体征好转时间短、住院时间缩短(P<0.05～P<0.01)。结论:阿奇霉素联合维生素D可以改善患儿气道炎症反应,提高机体抵抗力,改善患儿临床治疗疗效。

Efficacy of azithromycin combined with vitamin D in the treatment of asthma in children

Objective: To investigate the clinical efficacy of azithromycin combined with vitamin D in the treatment of asthma of children.Methods: Ninety children with bronchial asthma were randomly divided into the conventional therapy group(group A),Azithromycin group(group B) and azithromycin combined with vitamin D group(group C).The concentrations of serum interleukin(IL)-2 and IL-17 in all patients were measured before and after the treatment.The blood parameters,the time of symptoms and signs improvement and hospital stays between 3 groups were compared before and after the treatment.Results: The differences of serum IL-2 and IL-17 levels between 3 groups before treatment were not statistically significant(P>0.05).After the treatment,the levels of serum IL-2 and IL-17 in 3 groups increased and decreased,respectively(P<0.01),especially for group C(P<0.05 to P<0.01).The time of symptoms and signs improvement and hospital stays in group C were shorter than those in group A and B(P<0.05 to P<0.01).Conclusions: The treatment of azithromycin combined with vitamin D can improve the airway inflammation,body's resistance and clinical efficacy in children.