X连锁凋亡抑制蛋白在膀胱癌的表达及其意义

目的:探讨X连锁的凋亡抑制蛋白(XIAP)在膀胱移行细胞癌(BTCC)的表达情况,以及XIAP与BTCC病理分级、临床分期的关系。方法:收集临床上经病理确诊的BTCC手术标本62例,应用免疫组织化学测定肿瘤组织中XIAP的表达情况,将结果进行相关分析。结果:XIAP在膀胱肿瘤中的阳性表达率为67.7%,在正常膀胱移行上皮阳性表达率为23.1%,两者差异有统计学意义(P<0.005);在Ⅰ、Ⅱ、Ⅲ级BTCC的阳性表达率分别是75.0%、57.9%和66.7%,在浅表性和浸润性BTCC的阳性表达率分别为63.9%和73.1%,阳性表达率各组之间无统计学意义(P>0.05)。结论:XIAP可能在BTCC的发生、发展中发挥重要作用。

Expression and significance of X-linked inhibitor of apoptosis protein in bladder cancer

Objective：To study the expression of X-linked inhibitor of apoptosis protein （XIAP） in bladder transitional cell carcinoma （BTCC） and to clarify the relationship between the pathological grades and clinical stages of BTCC. Methods： The epithelium speeiment of 62 cases of BTCC confirmed by pathological method were collected and the expression of XIAP was detected by using immunohistochemical assay（ SP methods）. Results：The positive expression rate of XIAP in BTCC was 67.7% ,which was significantly higher than that of normal bladder tissues （23.1% ） （P 〈 0.005 ）. The positive expression rates in grade Ⅰ , Ⅱ and Ⅲ were 75.0% , 57.9% and 66.7% , respectively; The positive expression rates in stage Ta-T1 and T2-T4 were 63.9% and 73. 1% , respectively. Conclusions ：It is suggested that high expression of XIAP may play an important role in the mechanisms of tumorignesis and development of BTCC,