| 血清乙型肝炎病毒核酸定量检测及临床意义 |
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| 引用本文： | 尚莉莉,任开祥.血清乙型肝炎病毒核酸定量检测及临床意义[J].蚌埠医学院学报,2007,32(5):560-561. |
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| 作者姓名： | 尚莉莉 任开祥 |
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| 作者单位： | 1. 安徽省蚌埠市传染病医院传染科, 233000;2. 安徽省蚌埠市第一人民医院消化内科, 233000 |
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| 摘 要： | 目的: 探讨血清HBV DNA水平与HBV标志物(HBVM)表现模式、肝损害程度的关系。方法: 采用荧光定量PCR分析系统检测126例乙肝病毒感染者HBV DNA,采用ELISA法检测HBVM。结果: 在HBsAg阳性+HBeAg阳性+抗HBc阳性的血清中HBV DNA阳性率和含量最高,血清HBeAg与HBV DNA含量有一定关系(P<0.01),血清丙氨酸氨基转移酶水平与HBV DNA含量亦有一定关系(P<0.05)。结论: HBV DNA含量与HBeAg有一定关系,肝脏损害程度与血清HBV DNA亦有一定关系。
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| 关 键 词： | 核酸类 乙型肝炎病毒 HBV标志物 丙氨酸氨基转移酶 聚合酶链反应 |
| 文章编号： | 1000-2200（2007）05-0560-02 |
| 收稿时间： | 2007-01-09 |
| 修稿时间： | 2007-01-09 |
Nucleic acid quantifying assay of hepatitis B virus and clinical significance |
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| SHANG Li-li,REN Kai-xiang.Nucleic acid quantifying assay of hepatitis B virus and clinical significance[J].Journal of Bengbu Medical College,2007,32(5):560-561. |
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| Authors: | SHANG Li-li REN Kai-xiang |
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| Institution: | 1. Department of Infections Diseases, Bengbu Infections Diseases Hospital, Bengbu 233000;2. Department of Gastroenterology, Bengbu First People's Hospital, Bengbu 233000, China |
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| Abstract: | Objective: To explore the relation between the nucleic acid content of hepatitis B virus (HBV) and HBV markers, liver injury. Methods: One hundred and twenty-six patients suffering from hepatitis B received HBV DNA analysis. Fluorescence ration PCR analysis was performed for HBV DNA quantifying assessment. HBV markers were detected by ELISA. Results: Serum HBeAg was related to HBV DNA (P<0.01). The highest HBV DNA levels were presented in sera positive for both HBsAg and HbeAg (P<0.05). Serum alanine amjnotransferase level and HBV DNA content were correlated. Conclusions: The quantity of HBV DNA is related to HbeAg. Liver injury stage is related to serum HBV DNA content. |
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| Keywords: | nucleic acids hepatitis B virus HBV markers alanine aminotransferase quantity polymerase chain reaction |
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