| 瘦素抵抗肥胖雌性大鼠肺通气功能的损伤研究 |
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| 引用本文： | 姚荣英,顾璇,郑玲.瘦素抵抗肥胖雌性大鼠肺通气功能的损伤研究[J].蚌埠医学院学报,2011,36(11):1181-1183. |
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| 作者姓名： | 姚荣英 顾璇 郑玲 |
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| 作者单位： | 蚌埠医学院预防医学系,安徽,蚌埠,233030;蚌埠医学院护理系,安徽,蚌埠,233030;蚌埠医学院生理学教研室,安徽,蚌埠,233030 |
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| 基金项目： | 安徽省教育厅自然科学研究资助项目(KJ2008B12ZC) |
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| 摘 要： | 目的：观察高脂饮食诱导的瘦素抵抗肥胖大鼠肺通气功能（PVF）的变化。方法：将30只SD雌性刚离乳大鼠按体重随机分成对照组和高脂组各15只;对照组给予普通饲料喂养,高脂组给予高脂饲料喂养,第8周末按体重增量从高脂组中筛选出7只大鼠作为瘦素抵抗肥胖组,测定2组大鼠的体重、血清瘦素浓度及潮气量（TV）、肺通气量（PV）、用力肺活量（FVC）、最大呼气中段流量（MMEF）、吸气峰流量（PIF）和呼气峰流量（PEF）。结果：瘦素抵抗肥胖组第3周末至第8周末大鼠的体重和第8周末血清瘦素浓度、PV、PIF与PEF均高于对照组（P〈0.05～P〈0.01）,TV、FVC和MMEF差异均无统计学意义（P〉0.05）。结论：饮食诱导的瘦素抵抗性肥胖降低了雌性大鼠的PVF。
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| 关 键 词： | 肥胖 瘦素抵抗 肺通气功能 大鼠 |
Study on the pulmonary ventilation function in obese female rats with leptin resitance |
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| YAO Rong-ying,GU Xuan,ZHENG Ling.Study on the pulmonary ventilation function in obese female rats with leptin resitance[J].Journal of Bengbu Medical College,2011,36(11):1181-1183. |
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| Authors: | YAO Rong-ying GU Xuan ZHENG Ling |
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| Institution: | YAO Rong-ying1,GU Xuan2,ZHENG Ling3(1.Department of Preventive Medicine,2.Department of Nursing,3.Department of Physiology,Bengbu Medical College,Bengbu Anhui 233030,China) |
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| Abstract: | Objective:To explore the changes of pulmonary ventilation function(PVF) in obese rats with leptin resistance induced by high-fat diet.Methods:Thirty female Sprague-Dawley weaning rats were randomly divided into control group and high-fat diet group according to their body weight.Fifteen rats were fed with basic diet and 15 rats were fed with high-fat diet.At the end of the 8th week,7 obese rats were selected by body weight from high-fat diet group as obese group with leptin resistance.The body weight,blood ... |
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| Keywords: | obesity leptin resistance pulmonary ventilation function rats |
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