紫杉醇联合亚叶酸钙和5-氟尿嘧啶治疗晚期胃癌临床观察

目的:观察紫杉醇联合亚叶酸钙和5-氟尿嘧啶(5-Fu)治疗晚期胃癌的疗效和毒副反应.方法:55例晚期胃癌患者均给予紫杉醇135 mg/m2,第1天静脉滴注(静滴),亚叶酸钙200 mg/m2,静滴2 h,5-Fu 400 mg/m2,静脉推注后给予5-Fu 600 mg/m2静滴22 h,第1～3天,每3周重复,至少2个周期后评价疗效.结果:可评价疗效者55例,获得完全缓解3例,部分缓解27例,无变化15例,进展10例,总有效率(完全缓解+部分缓解)54.5%.主要毒副反应为骨髓抑制.结论:紫杉醇联合亚叶酸钙和5-Fu治疗晚期胃癌疗效好,毒副反应轻,患者可以耐受.

Clinical study of treatment of advanced gastric cancer with paclitaxel combined with leucovorin and 5-fluorouracil

Objective:To evaluate the clinical efficacy and side effects of paclitaxel combined with leucovorin and 5-fluorouracil(5 Fu) treating advanced gastric cancer.Methods:Fifty-five patients with advanced gastric cancer were treated with 135 mg/m2 of paclitaxel by intravenous drip on the first day,and 200 mg/m2 of leucovorin for 2 hours by intravenous drip and 600 mg/m2 of 5-Fu were given by intravenous drip for 22 hours after 400 mg/m2 of 5-Fu by intravenous injection from 1 st to 3 rd.The treatment was repeated after 3 weeks.The effects were evaluated at least two cycles therapy.Results:Among 55 cases of advanced gastric cancer,there were complete response in 3 cases,partial response in 27 cases,no change in 15 cases and progression in 10 cases.The total effective rates was 54.5%,and the main toxicity was myelosuppression.Conclusions:Treatment of advanced gastric cancer with paclitaxel combined with leucovorin and 5-Fu effective andlight side effects,and patients can tolerate.