加减香砂六君子汤对功能性消化不良小鼠血清白细胞介素的影响

目的:探讨加减香砂六君子汤联合西药对功能性消化不良(FD)小鼠白细胞介素(IL)-2、IL-4、IL-6的影响.方法:采用不规则饮食喂养和饮用酸化水的方法建立FD模型,将小鼠随机分为正常组、模型组、中药组、西药组、中西药联合组,分别给予相应的治疗,观察动物的一般状态,测量小鼠血清IL-2、IL-4、IL-6的水平.结果:模型组在体质量上低于西药组(P<0.05),显著低于正常组、中药组、中西药联合组(P<0.01);西药组显著低于中西药联合组(P<0.01).模型组饮食量显著低于正常组、西药组、中药组(P<0.01),西药组饮食量低于中药组(P<0.05),显著低于中西药联合组(P<0.01).给药组与模型相比,IL-2、IL-4、IL-6的水平明显降低(P<0.01),与西药组相比,中药组和中西药联合组IL-4、IL-6的水平明显降低(P<0.01),中西药联合组IL-6的水平较中药组明显降低(P<0.01).结论:加减香砂六君子汤可以提高免疫能力以达到治疗功能性消化不良的目的;加减香砂六君子汤对治疗功能性消化不良小鼠相对于西药吗丁啉有较强的优势,但中西联合用药更能发挥各自优势来达到更好的治疗目的.

Effect of the addition and subtraction Xiangsha Liujunzi Decoction on the serum interleukin level in mice with functional dyspepsia

Objective:To investigate the effects of addition and subtraction Xiangsha Liujunzi Decoction on the levels of serum interleukin(IL)-2,IL-4 and IL-6 in mice with functional dyspepsia(FD).Methods:The FD model of mice was established by irregular diet and drinking acidification water,and randomly divided into the normal group,model group,Chinese medicine group,western medicine group and combination group.The general state of mice was observed,and the serum levels of IL-2,IL-4 and IL-6 in mice were measured.Results:The body mass in model group was lower than that in Western medicine group(P<0.05),which was significantly lower than that in control group,Chinese medicine group and combination group(P<0.01),and the body mass in western medicine group was significantly lower than that in combination group(P<0.01).The food consumption in model group was significantly lower than that in control group,western medicine group and Chinese medicine group(P<0.01).The food consumption in western medicine group was lower than that in Chinese medicine group(P<0.05),and significantly lower than that in combination group(P<0.01).Compared with the model group,the levels of IL-2,IL-4 and IL-6 in medication administration groups significantly decreased(P<0.01).Compared with the western medicine group,the slevels of IL-4 and IL-6 in Chinese medicine group and combination group significantly decreased(P<0.01).Compared with the Chinese medicine group,the slevels of IL-6 in combination group significantly decreased(P<0.01).Conclusions:The add and subtract Xiangshaliujunzitang can improve the immune ability so as to achieve the purpose of the treatment of functional dyspepsia.And its curative effect havea strong advantage over Motilium.But the combination of Chinese and Western medicine can give full play to their advantages to achieve better therapeutic purposes.