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系统性红斑狼疮抗SmD1抗体与SmD1抗原mRNA水平的关系
引用本文:王奔放,陈兴国,曾庆娣,王自正.系统性红斑狼疮抗SmD1抗体与SmD1抗原mRNA水平的关系[J].蚌埠医学院学报,2010,35(11):1141-1143.
作者姓名:王奔放  陈兴国  曾庆娣  王自正
作者单位:东南大学附属江阴市人民医院,检验科,江苏,江阴,214400;江苏省南京临床核医学中心,210006
摘    要:目的:分析SmD1抗原的mRNA水平与抗SmD1抗体的关系。方法:收集30例抗SmD1抗体升高的系统性红斑狼疮(SLE)患者、30例抗SmD1抗体正常的SLE患者、30名健康体检者的血标本。用荧光定量RT-PCR检测SLE组和正常对照组SmD1抗原的mRNA水平。所得数据应用SPSS11.5软件包进行统计分析。结果:抗SmD1抗体升高、抗SmD1抗体正常的SLE患者以及正常对照组中,SmD1抗原的荧光定量PCR结果-△△CT分别为-0.60±2.99、-0.04±1.92和-0.00±2.80,差异无统计学意义(P〉0.05)。结论:SmD1基因的表达在各组中无明显不同,SLE患者免疫异常,表型特别丰富,几乎涉及整个免疫系统,仅以SmD1mRNA表达异常不可能完全解释免疫系统的紊乱。

关 键 词:红斑狼疮  全身性  抗SmD1抗体  荧光定量PCR

Relationship between level of anti-SmD1 antibody and the mRNA level of SmD1 antigen in patients with systemic lupus erythematosus
WANG Ben-fang,CHEN Xing-guo,ZENG Qing-di,WANG Zi-zheng.Relationship between level of anti-SmD1 antibody and the mRNA level of SmD1 antigen in patients with systemic lupus erythematosus[J].Journal of Bengbu Medical College,2010,35(11):1141-1143.
Authors:WANG Ben-fang  CHEN Xing-guo  ZENG Qing-di  WANG Zi-zheng
Institution:WANG Ben-fang1,CHEN Xing-guo2,ZENG Qing-di2,WANG Zi-zheng2(1.Department of Clinical Laboratory,Jiangyin Hospital Affiliated Medical College of South-East University,Jiangyin Jiangsu 214400,2.Nanjing Clinical Nuclear Medicine Center,Nanjing Jiangsu 210006,China)
Abstract:Objective:To analyze the relationship between the mRNA level of SmD1 antigen and the level of anti-SmD1 antibod in patients with systemic lupus erythematosws(SLE).Methods:The blood samples from 30 SLE patients with high level of anti-SmD1 antibody,30 cases with normal level of anti-SmD1 antibody and 30 normal controls were collected.The mRNA level of SmD1 antigen was detected by real-time PCR in all the cases.SPSS11.5 was used for statistical analysis.Results:In the SLE patients with high level of anti-SmD1...
Keywords:lupus erythematosus  systemic  anti-SmD1 antibody  Real-time PCR  
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