| 磷脂酶A2与溶血磷脂酸在大鼠脑缺血性损伤后的表达及相互关系研究 |
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| 引用本文： | 史树海,牛建平,王颖慧,程景丽. 磷脂酶A2与溶血磷脂酸在大鼠脑缺血性损伤后的表达及相互关系研究[J]. 内蒙古医学杂志, 2009, 41(5): 516-518 |
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| 作者姓名： | 史树海 牛建平 王颖慧 程景丽 |
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| 作者单位： | 包头医学院2006级研究生,内蒙古,包头,014010;厦门市第二医院神经内科,福建,厦门,361003;包头医学院第一附属医院神经内科,内蒙古,包头,014010 |
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| 摘 要： | 目的：研究大鼠脑缺血损伤后,脂蛋白磷脂酶A2（Lp-PLA2）与溶血磷脂酸（LPA）的表达及相互关系。方法：雄性Wistar大鼠30只,随机分为假手术组,脑缺血组,然后制作MCAO大鼠动物模型,记录大鼠的神经功能缺损情况,应用化学法检测LPA以及运用ELISA酶解法检测Lp-PLA2。结果：大鼠脑缺血后缺血组各时间点血清中PLA2、LPA的表达,同假手术组相比均明显增高,且差异有统计学意义（P〈0.05）。结论：Lp-PLA2和LPA二者可能是脑缺血损伤的独立危险因素。
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| 关 键 词： | 脂蛋白磷脂酶A2 溶血磷脂酸 脑缺血 |
Expression of Lp-PLA2 and LPA in Rabbit's Cerebral Ischemia and Their Correlationship |
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| SHI Shu-hai,NIU Jian-ping,WANG Ying-hui,CHENG Jing-li. Expression of Lp-PLA2 and LPA in Rabbit's Cerebral Ischemia and Their Correlationship[J]. Inner Mongolia Medical Journal, 2009, 41(5): 516-518 |
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| Authors: | SHI Shu-hai NIU Jian-ping WANG Ying-hui CHENG Jing-li |
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| Affiliation: | 1.Postgraduate in Grade 2006;Baotou Medical College;Baotou 014010 China;2.Department of Neurology;The Second Hospital of Xiamen City;Xiamen 361003 China;3.Department of Neurology;The Affiliated Hospital of Baotou Medical College;Baotou 014010 China |
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| Abstract: | Objective:To investigate the expression of Lp-PLA2 and LPA in rabbit's cerebral ischemia and their correlationship.Methods:Male wistar rabbits were randomly divided into group with pseudo-opeation and group with cerebral ischemia,then the model of MCAO was established.The nerve dysfuction was recorded and the level of LPA and Lp-PLA2 was detected by chemical methods and ELISA methods respectively.Results:The expression of PLA2 and LPA on various time after cerebral ischemia was statistically higher than tho... |
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| Keywords: | Lp-PLA2 Cerebral ischemia LPA |
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