二金汤对实验性功能性消化不良大鼠胃排空和胃肠激素的影响

目的 :观察二金汤对大鼠胃排空和胃肠激素的影响 ,探讨其可能的作用机制。方法 :采用不规则进食加稀酸喂养制作大鼠功能性消化不良 (FD)模型 ,并随机分成大、小剂量二金汤、吗丁啉、生理盐水、模型组共 5组 ,连续给药 2 8d后 ,放免法检测血浆胃动素和血清胃泌素含量 ;以酚红法观察胃排空。结果 :与正常组相比 ,模型组胃排空和血浆胃动素含量显著降低 (P <0 .0 5 ) ;大剂量二金汤组与吗丁啉组比模型组显著升高 (P <0 .0 5 ) ;各组血清胃泌素含量无差异 (P >0 .0 5 )。结论 :二金汤具有促进内源性胃动素释放和胃排空作用 ,可能是其治疗功能性消化不良的机制之一。

EFFECTS OF ERJIN DECOCTION ON GASTRIC EMPTYING AND GASTROINTESTINAL HORMONE OF RATS WITH FUNCTIONAL DYSPEPSIA

Objective:to observe the effects of erjin decoction on the gastric emptying and gastrointestinal hormone of rats and study its mechanism. Methods: functional dyspepsia models in rats were made by irregularly feeding food plus diluted hydrochloric acid and divided randomly into 5 groups ——high and low dosages of erjin decoction,domperidone tablets,saline and model groups. Treatments were offered for 28 days. The content of motilin in plasma and gastrin in serum were determined by radiommunoassay.And gastric emptying was observed with phenolsulfonphthalein.Results:compared with that in the normal control group,the content of motilin and gastric emptying in the model groups were obviously decreased(P<0.05), while increased significantly in the high dosage of erjin decoction and domperidone tablets groups(P<0.05 or P<0.01).However,the concentration of gastrin in serum had no significantly difference(P>0.05)in all groups.Conclusion:erjin decoction had the effects of promoting the release of motilin and gastric emptying.It might be the mechanism of functional dyspepsia.