中西药物对多囊卵巢综合征生殖和代谢功能的影响

为探讨石英毓麟汤配合氯米芬对肾虚血瘀型多囊卵巢综合征 (PCOS)患者生殖与代谢功能的调节作用 ,采用放射免疫法对 35例 PCOS患者治疗前后及 15例月经周期正常的健康妇女进行血清瘦素 (leptin)、促卵泡激素 (FSH)、黄体生成素 (L H)、睾酮 (T)、胰岛素 (INS)的测定。比较治疗前后及其与对照组的血清 leptin、FSH、L H、T、INS水平的差异 ,并分析 leptin与 FSH、L H、T、INS的相关性。结果表明 :高 L H血症、高 INS血症、高 T血症及高 leptin血症是 PCOS患者四种重要的生化改变 ;石英毓麟汤配合氯米芬可以从生殖和代谢两方面 ,调节肾虚血瘀型 PCOS患者失调的内环境 ,促使其恢复生殖功能和能量代谢的平衡 ;肾虚和血瘀是 PCOS的两个重要中医病机

EFFECTS OF CHINESE AND WESTERN MEDICINE ON FUNCTION OF REPRODUCTION AND METABOLISM IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Objective:To investigate the regulatory effects of Shiying Yulin decoction(SYD) and clomiphene citrate(CC) on function of reproduction and metabolizsm in polycystic ovary syndrome(PCOS) patients with deficiency of kidney and blood stasis syndrome(DKBSS).Methods:Immunoradioassay was used to measure the serum levels of leptin,follicle stimulating hormone(FSH),luteinizing hormone(LH),testesterone(T)and insulin(INS) in PCOS women (n=35) with deficiency of kidney and blood stasis syndrome and normal controls (n=15) to access changes in leptin,FSH,LH,T and INS levels and the relationship among leptin and FSH,LH,T,INS.Results:Serum leptin,LH,LH/FSH,T and INS levels in women with PCOS before treatment were significantly higher than those in controls.In both groups fast leptin levels were significantly correlated with BMI and INS while no significant correlation were found with FSH,LH and T.SYD and CC could decrease serum leptin,LH,LH/FSH,T and INS levels in patients with PCOS significantly while having no significantly influence on serum FSH levels.Conclusion: High serum leptin,serum LH,serum FSH,serum T levels are four of important biochemical changes in PCOS patients with DKBSS.SYD and CC can regulate the unbalanced inner enviroment in PCOS patients from the points of reproduction and metabolism and then recuperate their reproductive function and balance their energy metabolism.The deficiency of kidney and the blood stasis are the important pathology of PCOS from the point of view of Chinese traditional medicine.